The exact causes are unclear. Current evidence suggests that hyperglycemia and hyperlipidemia (persistently high blood glucose and lipids) drive neuronal oxidative stress and chronic low-grade inflammation, leading to nerve damage. [1][2][3]
What causes diabetic neuropathy?
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•Last Updated: May 16, 2025
The exact causes of diabetic neuropathy are not fully understood, but it is believed that persistently high blood glucose and lipids contribute to neuronal oxidative stress and chronic low-grade inflammation, which result in nerve damage.