While the cause of colic has not been established, there are several different factors that may contribute. These include gastrointestinal factors (such as gut flora, food intolerances, feeding frequency, inflammation and gastrointestinal immaturity), neurodevelopmental factors (such as increased intestinal motility), and drug-based factors (such as maternal smoking). Interactions between some of these factors are likely as well.[1][2]
What causes infantile colic?
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•Last Updated: May 16, 2025
The exact cause of infantile colic is not known, but it may be influenced by various factors, including gastrointestinal issues, neurodevelopmental aspects, and maternal behaviors like smoking. Additionally, interactions between these factors could play a role in the condition.