The narrowing or blockage of arteries in peripheral arterial disease is caused by a progressive build-up of fatty plaques in the lining of the affected artery.[1] This complex process is called atherosclerosis, and it is influenced by genetics and promoted by lifestyle factors such as smoking, diet, physical inactivity, and excessive weight gain.[1]
What causes peripheral arterial disease?
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•Last Updated: May 16, 2025
Peripheral arterial disease is caused by the narrowing or blockage of arteries due to a progressive build-up of fatty plaques, a process known as atherosclerosis. This condition is influenced by genetic factors and is exacerbated by lifestyle factors such as smoking, poor diet, lack of physical activity, and excessive weight gain.