What causes male sexual dysfunction?

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    Last Updated: May 16, 2025

    Male sexual dysfunction can be caused by a variety of factors, including neurological, vascular, endocrine, and psychosocial issues, as well as sleep disturbances, medications, and recreational drugs. Any disruption in the normal functioning of these systems can lead to sexual function problems.

    “Normal” sexual function requires vascular, neurological, hormonal, and psychological systems to function together. As such, issues with any of these symptoms may produce issues with sexual function.[1]

    Sexual dysfunction can be caused by:

    • Neurological issues (e.g., damage to the brain, the spinal cord, or the nerves of the penis)
    • Vascular issues (e.g., reduced penile blood flow due to cardiovascular disease)
    • Endocrine issues (e.g., low testosterone, high prolactin, high/low thyroid hormones)
    • Psychosocial issues (e.g., depression, stress, or relationship issues)[2]
    • Sleep disturbances
    • Medications (e.g., SSRIs, opioids, certain blood pressure medications)
    • Recreational drugs
    What causes male sexual dysfunction? - Examine