What has ibutamoren been studied for but shown no benefit?

There have been a few negative studies with ibutamoren. For example, there was interest in using ibutamoren for Alzheimer’s disease, because its ability to increase levels of insulin-like growth factor 1 (IGF-1) may theoretically reduce brain amyloidosis and slow down disease progression. However, a large randomized controlled trial in people with mild to moderate Alzheimer’s disease found that taking 25 mg of ibutamoren daily for 12 months is no different than a placebo for slowing down cognitive or physical decline.^[1] Additionally, there is interest in the use of ibutamoren for hypogonadism; however, ibutamoren has not been shown to increase testosterone levels.^[2] Ibutamoren has also not been shown to improve bone mineral density even though it seemed to activate biomarkers signaling bone resorption (breaking down).^[3]