Acetyl-L-carnitine is an acetylated form of L-carnitine (i.e., it has an acetyl functional group attached to it) that can cross the blood-brain barrier, and is claimed to have neurophysiological effects.[1] Supplementation with acetyl-L-carnitine shows some efficacy in improving the symptoms of depression[2] as well as minor benefits to some aspects of cognitive function.[3][4][5] However, higher-quality randomized controlled trials are needed to bolster the current evidence in these areas.
What is acetyl-L-carnitine?
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•Last Updated: October 13, 2024