Acetyl-L-carnitine is an acetylated form of L-carnitine (i.e., it has an acetyl functional group attached to it) that can cross the blood-brain barrier, and is claimed to have neurophysiological effects.[1] Supplementation with acetyl-L-carnitine shows some efficacy in improving the symptoms of depression[2] as well as minor benefits to some aspects of cognitive function.[3][4][5] However, higher-quality randomized controlled trials are needed to bolster the current evidence in these areas.
What is acetyl-L-carnitine?
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•Last Updated: May 16, 2025
Acetyl-L-carnitine is an acetylated form of L-carnitine that can cross the blood-brain barrier and is believed to have neurophysiological effects. It may help improve symptoms of depression and provide minor cognitive benefits, although more rigorous randomized controlled trials are needed to support these claims.