GlyNAC is simply a term used to describe co-administered glycine and <a href="/supplements/n-acetylcysteine/" class="popover" data-tooltip="<div><h6>N-Acetylcysteine</h6><p><em>N-acetylcysteine</em> (NAC) is a precursor for the amino acid L-cysteine. It has antioxidant, anti-inflammatory, and mucus thinning properties. NAC can act as a direct antioxidant, but more importantly, it provides the cysteine required for the production of glutathione, a powerful...</p></div>">N-acetylcysteine (NAC). Like NAC, GlyNAC is thought to reduce oxidative stress by increasing levels of <a href="/supplements/glutathione/" class="popover" data-tooltip="<div><h6>Glutathione</h6><p>Glutathione is an antioxidant used by every cell and tissue in the body. Although critical for a number of processes, it has limited use as dietary supplement due to rapid breakdown during oral ingestion. Its metabolite, L-cysteine, can increase glutathione...</p></div>">glutathione (the most abundant intracellular antioxidant).<a href="#ref-1" id="ref-link-1" class="ref-link popover" data-tooltip='<div><p class="mb-3">Sekhar RV. <a href="https://pubmed.ncbi.nlm.nih.gov/35052658" target="\_blank" rel="noopener noreferrer">GlyNAC (Glycine and -Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study.</a></p>Antioxidants (Basel) (2022-Jan-13)</div>'> [1]

What is GlyNAC?

Written by:

Nick Milazzo, Giulia Guerrini

Fact-checked

by:

Katie Jantz

•Last Updated: May 16, 2025

GlyNAC refers to the combination of glycine and N-acetylcysteine (NAC), which is believed to lower oxidative stress by boosting glutathione levels, the primary intracellular antioxidant.

Last Updated:May 16, 2025

GlyNAC is simply a term used to describe co-administered glycine and N-acetylcysteine (NAC). Like NAC, GlyNAC is thought to reduce oxidative stress by increasing levels of glutathione (the most abundant intracellular antioxidant).^[1]

What is GlyNAC?

References