Because apigenin is unstable and poorly bioavailable in isolation, much of what is known about apigenin’s clinical effect in humans comes from studies using the plants or foods that it comes from.[1][2][3][4][5] The formulation of the supplement may improve apigenin’s bioavailability, and some research has explored preparations such as enteric coated pellets[6] and carbon nanopowders.[7] However, preclinical studies examining bioavailability in both humans and animals using apigenin in an isolated form are typically done in a tightly controlled setting that does not reflect everyday use.[8][7][9]
What is known about apigenin’s clinical effect(s) on humans?
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•Last Updated: May 16, 2025
Apigenin's clinical effects in humans are primarily understood through studies of the plants and foods it originates from, due to its instability and poor bioavailability when isolated. Some research has investigated formulations like enteric-coated pellets and carbon nanopowders to enhance its bioavailability, but preclinical studies often occur in controlled settings that may not represent typical use.