Silymarin is a complex extracted from the dried seeds and fruits of the plant Silybum marianum (milk thistle). Silymarin contains a mixture of flavonolignans (silybin, isosilibinin, silichristin, and silidianin) and a flavonoid (taxifolin). Silybin is recognized as the primary bioactive component, constituting 50–70% of the extract, and commercial supplements are often standardized based on its content.[1][2][3][4]