The macronutrient content of a meal affects the amount of GLP-1 that’s released. GLP-1 is released mainly in response to the carbohydrates and fats in a meal. Protein stimulates GLP-1 release to a lesser extent.[1] This should not be interpreted as a license to eat large amounts of fat and carbs in order to boost your GLP-1 levels, though! A more promising way to healthily boost your GLP-1 levels is through exercise. GLP-1 seems to rise immediately after exercise, and baseline levels of GLP-1 in people who exercise remain elevated in the medium term, too.[2] Not only that, but exercise may help decrease GLP-1 resistance in people with type 2 diabetes and may make medications like semaglutide even more effective.[3]
What lifestyle interventions affect GLP-1 levels?
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•Last Updated: May 16, 2025
The macronutrient content of meals, particularly carbohydrates and fats, influences GLP-1 release, and protein has a lesser effect. Additionally, exercise can significantly boost GLP-1 levels, both immediately and in the medium term, and may enhance the effectiveness of medications for type 2 diabetes.