Evidence from twin and family studies on GERD have suggested that this condition may have about 31% heritability — meaning that a genetic influence can account for about one-third of the variation in GERD in the general population.[1] Identical twins are more likely to both have GERD than fraternal twins or non-twin family members,[2] and studies on families indicate a clear pattern of inheritance for GERD.[3] The role of specific genes in GERD has been elusive, though one study identified the C825T polymorphism in the GNB3 subunit gene as being significantly associated with GERD.[4]
What role does genetics play in GERD?
Written by:
Fact-checked
by:
•Last Updated: May 16, 2025
Genetics may account for approximately 31% of the variation in gastroesophageal reflux disease (GERD), as evidenced by twin and family studies that showed a higher prevalence among identical twins. Although a specific genetic polymorphism (C825T in the GNB3 subunit gene) has been associated with GERD, the exact role of specific genes remains unclear.