Multiple observational studies in people with SLE report an association between perceived stress and disease severity, such that increased stress exacerbates SLE symptoms.[1][2][3] While the mechanisms behind this connection are complex, stress induces changes in the central nervous system that may ultimately lead to immune system activation.[4] In people with SLE, this immune system activation is problematic, as it can spark the autoantibody “self-attack” that causes SLE symptoms. A stressful event, like exposure to trauma, may even be the environmental trigger that first provokes an SLE diagnosis.[5]
Considering the relationship between stress and SLE, it is important for people with SLE to find positive ways to manage their stress. This could include an exercise program,[6][7] a mindfulness practice,[8] social support,[9] behavioral therapy,[10][11] or another individualized approach.