Many supplements, particularly those with antioxidant or anti-inflammatory activity, have been investigated for their ability to reduce the severity or incidence of autoimmune disease. To date, some of the more promising evidence is for vitamin D and fish oil, which were linked to reduced incidence of autoimmunity in a large randomized controlled trial.[1] Further research is needed to better understand the way that supplements may affect the incidence or severity of autoimmunity in different people.
Which supplements are of most interest for autoimmune disease?
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•Last Updated: May 16, 2025
Supplements with antioxidant or anti-inflammatory properties, particularly vitamin D and fish oil, have shown promise in reducing the incidence of autoimmune disease, according to a large randomized controlled trial. However, further research is necessary to understand their effects on different individuals.