Supplementing melatonin doesn’t appear to affect the body’s own production in a negative way. Studies that have administered melatonin at doses of 0.5 mg,[1] 5.0 mg,[2] and 50 mg[1] have found no significant effect on the body's ability to produce a basal level of melatonin. One trial even found that people with insomnia who took 2 mg of melatonin nightly for 6 months had higher natural melatonin synthesis after cessation of the supplement than a historical sample of participants with insomnia who didn't take melatonin.[3]
Will supplementing melatonin affect my own production of melatonin?
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•Last Updated: May 16, 2025
Supplementing with melatonin does not negatively affect the body's own production of melatonin because studies show no significant effects on natural synthesis. In fact, one trial indicated that participants with insomnia who were taking melatonin had increased natural production after stopping the supplement.