Hypotheses about the possible carcinogenic effects of ASBs in humans come from carcinogenicity observed in rodent studies. However, carcinogenic effects like those seen in rodents have not been seen in humans. 4-methylimidazole (4-MEI), which is what gives cola its brown color, was associated with cancer in extremely large doses in rodents but does not appear to be carcinogenic in humans at the moderate doses found in ASBs.[1]
A tenuous association has been found between leukemia and ASB intake. However, there is not yet a lot of evidence to support this association; the evidence to date is from small studies that are not conclusive.[2][3]
Obesity-related cancers are not associated with ASB intake.[4][5][6][7]
References
- ^Moon JK, Shibamoto TFormation of carcinogenic 4(5)-methylimidazole in Maillard reaction systems.J Agric Food Chem.(2011-Jan-26)
- ^Yin T, Li J, Wang Y, Liu K, Long T, Cheng LArtificially Sweetened Beverage Consumption and Cancer Risk: A Comprehensive Dose-Response Meta-Analysis of Prospective Studies.Nutrients.(2022-Oct-22)
- ^Schernhammer ES, Bertrand KA, Birmann BM, Sampson L, Willett WC, Feskanich DConsumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and womenAm J Clin Nutr.(2012 Dec)
- ^Bondarev GI, Ponomareva AGDetermination of the human requirements for the basic foodstuffs by using nomograms.Feldsher Akush.(1986-Feb)
- ^Yan-Bo Zhang, Yi-Wen Jiang, Jun-Xiang Chen, Peng-Fei Xia, An PanAssociation of Consumption of Sugar-Sweetened Beverages or Artificially Sweetened Beverages with Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort StudiesAdv Nutr.(2021 Mar 31)
- ^Alfred Jatho, Jansen Marcos Cambia, Seung-Kwon MyungConsumption of artificially sweetened soft drinks and risk of gastrointestinal cancer: a meta-analysis of observational studiesPublic Health Nutr.(2021 Dec)
- ^Hodge AM, Bassett JK, Milne RL, English DR, Giles GGConsumption of sugar-sweetened and artificially sweetened soft drinks and risk of obesity-related cancers.Public Health Nutr.(2018-Jun)