CYP2E1 Substrates

    CYP2E1 substrates include, but are not limited to, acetaminophen, ethanol, and theophylline. See glossary page for more information.

    Summary

    CYP2E1 substrates are compounds that are metabolized by CYP2E1 (a cytochrome P450 enzyme), but do not necessarily affect its activity.

    In the presence of CYP2E1 inhibitors or inducers, the metabolism of CYP2E1 substrates can be affected.

    The table below outlines some of the most common or clinically relevant CYP2E1 substrates.[1][2][3] Importantly, this list is not exhaustive.

    CYP2E1 Substrates
    Acetaminophen
    Theophylline
    Ethanol

    References

    1. ^Song Y, Li C, Liu G, Liu R, Chen Y, Li W, Cao Z, Zhao B, Lu C, Liu YDrug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes.Clin Pharmacokinet.(2021-May)
    2. ^Zanger UM, Schwab MCytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Pharmacol Ther.(2013-Apr)
    3. ^Hakkola J, Hukkanen J, Turpeinen M, Pelkonen OInhibition and induction of CYP enzymes in humans: an update.Arch Toxicol.(2020-Nov)