Summary
OATP1B3 substrates include drugs that use OATP1B3 — an organic anion-transporting polypeptide — for transport into cells in the body. OATP1B3 transporters are found primarily in the liver, where they can facilitate the entry of OATP1B3 substrates into the liver for metabolism and/or excretion.[1][2][3]
Certain foods, medications, or supplements may alter OATP1B3 activity, potentially causing drug interactions by affecting the pharmacokinetics of drugs that are OATP1B3 substrates.
The table below outlines identified OATP1B3 substrates.[2][3][4] Importantly, this list is not exhaustive.
| OATP1B3 Substrates |
|---|
| Bosentan |
| Carboplatin |
| Cefadroxil |
| Cefazolin |
| Cephalexin |
| Cisplatin |
| Diclofenac |
| Digoxin |
| Docetaxel |
| Enalapril |
| Erythromycin |
| Fexofenadine |
| Fluvastatin |
| Hydroxyurea |
| Imatinib |
| Meselazine |
| Methotrexate |
| Nafcillin |
| Olmesartan |
| Oxaliplatin |
| Paclitaxel |
| Penicillin G |
| Pitavastatin |
| Rifampicin |
| Rosuvastatin |
| Saquinavir |
| Sorafenib |
| Telmisartan |
| Valsartan |
References
- ^Kalliokoski A, Niemi MImpact of OATP transporters on pharmacokinetics.Br J Pharmacol.(2009 Oct)
- ^Roth M, Obaidat A, Hagenbuch BOATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies.Br J Pharmacol.(2012 Mar)
- ^Kovacsics D, Patik I, Özvegy-Laczka CThe role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions.Expert Opin Drug Metab Toxicol.(2017 Apr)
- ^Yu J, Zhou Z, Tay-Sontheimer J, Levy RH, Ragueneau-Majlessi IIntestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings.J Pharm Sci.(2017 Sep)