HAMLET and Whey

Written by and verified by the Examine.com Research Team. Last updated on Sep 5, 2012.

Rather than being literature, HAMLET, as it applies to nutraceuticals, refers to the protein called 'Human Alpha-Lactalbumin made lethal to tumors'. It (alpha-lactalbumin) is a protein found in Whey Protein and milk in general (including breast milk) and it binds to oleic acid, the primary fatty acid in eggs and Olive Oil

It is a highly interesting research molecule since it appears that the addition of oleic acid dose dependently unfolds the protein, and this new meta-protein is then able to selectively kill tumor cells, unhealthy cells and young cells, with no actual influence on healthy cells. Quite an effective anti-tumor agent.

It is thought that it is formed in the body after consumption of bovine alpha-lactabumin (milk products) and human alpha-lactalbumin (breast milk in an infant); there seems to be no significant difference between the source of alpha-lactalbumin as both are potent.

Problems, however:

  • Currently, it is synthesized in vitro and used for research purposes

  • No study has yet identified it in vivo, despite both alpha-lactalbumin and oleic acid occurring in the body

  • No studies have been conducted on its oral ingestion and biological activity

It is an interesting topic since two food products can combine to create a wholly unique and novel protein, and it would be the definition of food-food interactions if merely putting olive oil in your whey (or, to a lesser extent, eating eggs with cheese) could confer anti-tumor activities by the combination.

Preliminary and interesting topic.

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"HAMLET and Whey," Examine.com, published on 5 September 2012, last updated on 5 September 2012, https://examine.com/nutrition/hamlet-and-whey/