Rodent studies of bergamot oil have shown evidence of pain relief and anti-inflammatory efficacy when the oil is applied directly to sore paws.[1][2] However, while human clinical trials have been planned, no results have been published as of 2024.[3][4]
References
- ^Navarra M, Mannucci C, Delbò M, Calapai GCitrus bergamia essential oil: from basic research to clinical application.Front Pharmacol.(2015)
- ^Scuteri D, Rombolà L, Hayashi T, Watanabe C, Sakurada S, Hamamura K, Sakurada T, Tonin P, Bagetta G, Morrone LA, Corasaniti MTAnalgesic Characteristics of NanoBEO Released by an Airless Dispenser for the Control of Agitation in Severe Dementia.Molecules.(2022 Aug 5)
- ^Paolo Tonin, MD, S. Anna Rehabilitation InstituteEfficacy of Defurocumarinized Bergamot in the Treatment of Agitation in Severe Dementia Patients (BEO). ClinicalTrials.gov identifier NCT04321889. Updated 2020-03-25. Accessed 2024-06-25.(2020-03-25)
- ^Scuteri D, Sandrini G, Tamburin S, Corasaniti MT, Nicotera P, Tonin P, Bagetta GBergamot rehabilitation AgaINst agitation in dementia (BRAINAID): Study protocol for a randomized, double-blind, placebo-controlled trial to assess the efficacy of furocoumarin-free bergamot loaded in a nanotechnology-based delivery system of the essential oil in the treatment of agitation in elderly affected by severe dementia.Phytother Res.(2021 Oct)