Is there any evidence that ibutamoren increases muscle mass or bone density?

Although ibutamoren might slightly increase muscle mass and bone density in older adults, its modest effect may not be worth the risk of overly high growth hormone levels. A clinical study showed that ibutamoren slightly increases muscle mass in older adults without known health conditions,^[1] but this doesn’t result in increased strength or improved function. There is also some evidence that ibutamoren, when added to the medication alendronate (which slows the breakdown of bones), increases the bone mineral density of the femoral neck but not any other locations.^[2]

In summary, although it’s recognized that growth hormone levels decrease with age, there’s no good evidence that artificially increasing growth hormone can reverse the natural aging process of muscle and bone.^[3]