There is a high level of variability between studies when it comes to the type and frequency of therapy sessions provided; the psychedelic medication type, dosage, and frequency; and the environment provided for the psychedelic sessions. Currently, the optimal psychedelic therapy protocol is not clear.

Most research has used psilocybin in dosages ranging from 20–45 mg per dose, either taken only once or taken twice with a separation of at least seven days between doses. Preliminary research suggests that protocols using higher doses (≥30 mg)^[1] and two psychedelic sessions^[2] may have better effects, although further research is needed to validate these findings. LSD is most commonly given as an oral dose of 200 μg, and ayahuasca dosing, while not well-defined, is generally based on weight and DMT content.^[3]