Our endocannabinoid system is involved in the regulation of emotional and stress responses as well as the consolidation and extinction (forgetting) of memories. Further, some evidence suggests that post-traumatic stress disorder (PTSD) may alter the function of the endocannabinoid system.[1] This has led to the question of whether THC may have a role in the management of PTSD.
Preliminary research has been somewhat promising, although studies have tended to be small, and only a few have been randomized controlled trials. THC may reduce some of the symptoms of PTSD, including a reduction in nightmares, improved sleep, and an increased sense of well-being.[1] Studies looking at brain function have also suggested that THC may reduce the reactivity of the amygdala (the part of the brain involved in detecting danger) in response to a threat, which may help facilitate emotional regulation and fear reduction.[2]
It’s important to consider that people with PTSD have an increased risk of substance use disorder (including cannabis use disorder) and may have other psychiatric conditions that could be worsened through THC exposure.[3] Additionally, an observational study suggested that over time, THC may worsen trauma-related intrusive thoughts.[4]
Clearly, more research is needed to better understand the potential benefits (and risks) of THC in PTSD.
References
- ^Steardo L Jr, Carbone EA, Menculini G, Moretti P, Steardo L, Tortorella AEndocannabinoid System as Therapeutic Target of PTSD: A Systematic Review.Life (Basel).(2021 Mar 9)
- ^Lotfinia S, Afshar A, Yaseri A, Olff M, Quidé YFunctional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials.Brain Behav.(2023 Dec)
- ^Anastasia S Suraev, Nathaniel S Marshall, Ryan Vandrey, Danielle McCartney, Melissa J Benson, Iain S McGregor, Ronald R Grunstein, Camilla M HoyosCannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studiesSleep Med Rev.(2020 May 16)
- ^Jane Metrik, Angela K Stevens, Rachel L Gunn, Brian Borsari, Kristina M JacksonCannabis use and posttraumatic stress disorder: prospective evidence from a longitudinal study of veteransPsychol Med.(2020 Jun 17)