Dyspareunia: How diet, lifestyle, and supplements may provide benefits.

Examine Database: Dyspareunia

Intervention	Grade	Evidence	Effect
Vitamins E And C	C	Participants: 59	Small Improvement
Vitamin D	C	Participants: 60	Small Improvement
Melatonin	C	Participants: 40	Moderate Improvement

Vitamins E And C

Participants: 59

Small Improvement

Vitamin D

Participants: 60

Small Improvement

Melatonin

Participants: 40

Moderate Improvement

Intervention	Grade	Effect	Detail
Vitamins E And C	C
Vitamin D	C
Melatonin	C

Research FeedRead all studies

Vitamin C and E for endometriosis pain

In this meta-analysis of randomized controlled trials, combined supplementation with vitamins C and E reduced pelvic pain in women with endometriosis.

Supplements for menstrual cramps and pelvic pain in women with endometriosis

Examine Database References

Vitamins E And C - Nalini Santanam, Nino Kavtaradze, Ana Murphy, Celia Dominguez, Sampath ParthasarathyAntioxidant supplementation reduces endometriosis-related pelvic pain in humansTransl Res.(2013 Mar)
Vitamin D - Abolfazl Mehdizadehkashi, Samaneh Rokhgireh, Kobra Tahermanesh, Neda Eslahi, Sara Minaeian, Mansooreh SamimiThe effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosisGynecol Endocrinol.(2021 Jan 29)
Melatonin - André Schwertner, Claudia C Conceição Dos Santos, Gislene Dalferth Costa, Alícia Deitos, Andressa de Souza, Izabel Cristina Custodio de Souza, Iraci L S Torres, João Sabino L da Cunha Filho, Wolnei CaumoEfficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trialPain.(2013 Jun)