Irritability: How diet, lifestyle, and supplements may provide benefits.

Examine Database: Irritability

Intervention	Grade	Evidence	Effect
Cannabis	D	Participants: 1132	No effect
Chaste tree	B	Participants: 195	Small Improvement
N-Acetylcysteine	B	Participants: 56	Small Improvement
Ashwagandha		Participants: 130
Peppermint		Participants: 32
Kefir		Participants: 125
Krill Oil		Participants: 70
Royal Jelly		Participants: 55
16:8 Intermittent Fasting		Participants: 23

Cannabis

Participants: 1132

No effect

Chaste tree

Participants: 195

Small Improvement

N-Acetylcysteine

Participants: 56

Small Improvement

Participants: 130

Participants: 32

Participants: 125

Participants: 70

Participants: 55

16:8 Intermittent Fasting

Participants: 23

Intervention	Grade	Effect	Detail
Cannabis	D
Chaste tree	B
N-Acetylcysteine	B
Ashwagandha
Peppermint
Kefir
Krill Oil
Royal Jelly
16:8 Intermittent Fasting

Research FeedRead all studies

Evaluating treatments for reducing irritability in autism

In this meta-analysis of randomized controlled trials, several pharmaceutical drugs reduced irritability in autistic people, but dietary supplements did not. Parent training was also effective for reducing irritability in autistic children.

Probiotic supplementation may improve psychological symptoms of premenstrual syndrome

Examine Database References

Chaste tree - Momoeda M, Sasaki H, Tagashira E, Ogishima M, Takano Y, Ochiai KEfficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label studyAdv Ther.(2014 Mar)
Cannabis - Zajicek JP, Sanders HP, Wright DE, Vickery PJ, Ingram WM, Reilly SM, Nunn AJ, Teare LJ, Fox PJ, Thompson AJCannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow upJ Neurol Neurosurg Psychiatry.(2005 Dec)
Royal Jelly - Georgiev DB, Metka M, Huber JC, Goudev AR, Manassiev NEffects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trialMedGenMed.(2004 Dec 16)
Ashwagandha - Auddy, B, et alA Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled StudyJ Am Nut Assn.()
Kefir - Daniel J Merenstein, Jennifer Foster, Frank D'AmicoA randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the influence of Kefir (MILK) StudyArch Pediatr Adolesc Med.(2009 Aug)
N-Acetylcysteine - Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam RA randomized controlled pilot trial of oral N-acetylcysteine in children with autismBiol Psychiatry.(2012 Jun 1)
Chaste tree - Zamani M, Neghab N, Torabian STherapeutic effect of Vitex agnus castus in patients with premenstrual syndromeActa Med Iran.(2012)
Cannabis - Zajicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A, Thompson A, UK MS Research GroupCannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trialLancet.(2003 Nov 8)
16:8 Intermittent Fasting - Kelsey Gabel, Kristin K Hoddy, Krista A VaradySafety of 8-h time restricted feeding in adults with obesityAppl Physiol Nutr Metab.(2019 Jan)
Krill Oil - Sampalis F, Bunea R, Pelland MF, Kowalski O, Duguet N, Dupuis SEvaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrheaAltern Med Rev.(2003 May)
Peppermint - Göbel H, Schmidt G, Soyka DEffect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parametersCephalalgia.(1994 Jun)
N-Acetylcysteine - Ghanizadeh A, Moghimi-Sarani EA randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disordersBMC Psychiatry.(2013 Jul 25)