Evidence-based

Net Acid Excretion

•Last Updated: October 13, 2024

Urine net acid excretion can be estimated by calculating ammonium (NH4+) plus measured urine titratable acidity (TA) minus serum icarbonate (HCO3).[reference|url=https://pubmed.ncbi.nlm.nih.gov/20072112|title=Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR|published=2010 Apr|authors=Sorot Phisitkul, Apurv Khanna, Jan Simoni, Kristine Broglio, Simon Sheather, M Hasan Rajab, Donald E Wesson|journal=Kidney Int|]

1,169 participants in 2 trials

Examine Evidence Grades

Last Updated:October 13, 2024

1,169 participants in 2 trials

Examine Evidence Grades

Examine Database: Net Acid Excretion

B

Participants: 154

Small Decrease

Fruits And Vegetables

C

Participants: 108

Moderate Decrease

Sodium Bicarbonate

C

Participants: 108

Small Decrease

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Intervention	Grade	Effect	Detail
Potassium	B
Fruits And Vegetables	C
Sodium Bicarbonate	C
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Examine Database References

Sodium Bicarbonate - Nimrit Goraya, Jan Simoni, Chan-Hee Jo, Donald E WessonTreatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rateKidney Int.(2014 Nov)
Potassium - H Lambert, L Frassetto, J B Moore, D Torgerson, R Gannon, P Burckhardt, S Lanham-NewThe effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysisOsteoporos Int.(2015 Jan 9)

Net Acid Excretion: How diet, lifestyle, and supplements may provide benefits.