Genetically predicted higher coffee consumption was causally associated with the following health outcomes:

Cancer: A higher risk of esophageal cancer but a lower risk of ovarian cancer and hepatocellular carcinoma (a type of liver cancer)
Brain health: A higher risk of Alzheimer’s disease and a younger age of onset for Huntington’s disease but a lower risk of migraines
Joints: A higher risk of osteoarthritis
Eyes and vision: A higher risk of glaucoma
Kidneys and gallbladder: A lower risk of kidney stones, chronic kidney disease, and gallstones
Metabolic and heart: A higher risk of obesity, type 2 diabetes and higher levels of LDL cholesterol. However, there was no consistent association with other cardiovascular conditions.

Can genetics explain the health effects of coffee? Original paper