The study included genetic data from more than 560,000 participants. This covered more than 89,000 participants who took glucosamine and over 90,000 participants with type 2 diabetes from 2 large genome-wide association studies (studies that examine many genetic variants across the genome to find links to traits or behaviors).

The odds of developing type 2 diabetes were 92% lower in the participants who were genetically predicted to be more likely to take glucosamine.

This association remained strong even after adjusting for confounders like weight, smoking, alcohol use, and total cholesterol.

Beyond joint health: Can glucosamine reduce the risk of type 2 diabetes? Original paper