A total of 407 adults (mostly women) with chronic migraines were included.

Most of the interventions involved dietary changes or supplementation with omega-3 fatty acids (1.5 grams per day from a combination of EPA and DHA or 1.8 grams per day of EPA). One study used alpha-lipoic acid (600 milligrams per day), rather than omega-3 fatty acids. Although alpha-lipoic acid is not a fatty acid, lower levels of alpha-lipoic acid have been noted among some individuals with migraine headaches.^[1]

Migraine intensity and frequency were reduced with large effect sizes, and duration was reduced with a moderate effect size. Scores on the Headache-Related Quality of Life scale also improved with a large effect size..

Can fatty acids reduce migraine severity? Original paper