The intervention durations ranged 1 to 36 months, and the isoflavone supplement dosages were 2 to 600 milligrams per day.

Isoflavone changed markers of bone turnover as follows:

Decreased (improved) 2 of 6 bone resorption markers
- β-cross-linked C-telopeptide of type 1 collagen (−0.094 ng/mL)
- Pyridinoline (large effect size)
Altered bone mineral concentrations
- Blood calcium levels (+0.34 mg/dL)
- Blood phosphorus levels (−0.065 mg/dL)
Increased 1 of 4 bone metabolism–regulating hormones
- IGF-1 (+9.8 ng/mL)

There were no changes in 4 markers of bone formation or 3 markers of osteoclast differentiation regulators.

Isoflavones for bone turnover in postmenopausal women Original paper