The participants took 100 to 400 mg of coenzyme Q10 or a placebo daily for 8 to 24 weeks.

Supplementation lowered systolic blood pressure by 3.86 mmHg and diastolic blood pressure by 2.70 mmHg but had no effect on lipid levels, including total cholesterol, LDL-C, HDL-C, and triglycerides.

These results varied by age, dose, and duration, leading to noticeable heterogeneity. Blood pressure reduction was more pronounced in younger adults but absent in older ones. Smaller doses (<100 mg) and shorter durations (<12 weeks) proved more effective for blood pressure and improved some lipid outcomes, primarily in younger individuals.

The quality of the evidence was moderate, and most of the studies had a low risk of bias.

Can coenzyme Q10 improve blood pressure and lipid profiles? Original paper