Improvements in pain were noted in 3 out of 7 studies (43%) or in 3 out of 5 studies (60%) that used glucosamine as the only supplement.

Improvements in mouth opening were reported in 3 out of 7 studies (43%) or in 2 out of 5 studies (40%) that used glucosamine as the only supplement.

Summary of studies

Study	Sample size	Intervention	Outcome
Thie et al. 2001	45 participants	500 mg of glucosamine sulfate every 8 hours for 3 months	Improvements in functional pain compared to ibuprofen
Haghighat et al. 2013	60 participants	1,500 mg of glucosamine sulfate daily for 90 days	Improvements in pain intensity and mouth opening compared to ibuprofen
Damlar et al. 2015	34 participants	1,500 mg of glucosamine sulfate and 1,200 mg of chondroitin sulfate per day for 8 weeks	Improvements in mouth opening compared to tramadol
Nguyen et al. 2001	34 participants	250 mg of glucosamine hydrochloride and 200 mg of chondroitin sulfate 3 times per day for 3 months	No clear benefits compared to a placebo
Cahlin et al. 2011	59 participants	400 mg of glucosamine sulfate three times per day for 6 weeks	No clear benefits compared to a placebo
Yang et al. 2018	144 participants	480 mg of glucosamine hydrochloride 3 times per day for 3 months	Improvements in pain and mouth opening after 1 year (but not after 1 month)
Kılıç et al. 2021	26 participants	750 mg of glucosamine hydrochloride, 600 mg of chondroitin sulfate, and 350 mg of MSM twice per day for 3 months	No clear benefits compared to a control group

Can glucosamine help with osteoarthritis of the jaw? Original paper