What are Akarkara’s main benefits?

    Last Updated: October 25, 2023

    Cell culture (in vitro) experiments show that extracts from Anacyclus pyrethrum have antimicrobial and antioxidant activity.[1][2] Several animal studies have confirmed the antioxidant activity,[3][4] along with anti-inflammatory[5][3][4] and immunomodulatory effects.[6][7][8] Animal studies also show that extracts from Anacyclus pyrethrum can act as a painkiller,[5][9][3] have neuroprotective effects against seizures in models of epilepsy,[10][11][12][13] and enhance memory.[13][14] Further studies in male rats also find evidence of a benefit to sperm health (count, viability, and motility[15][16]) and libido.[17][18]

    Unfortunately, these effects have only been demonstrated in cell culture or animal experiments; no clinical data exist. Therefore, it is not currently possible to make conclusions about the potential efficacy of Akarkara supplements on human health. The only human data currently available is from a study of 13 women in whom a 12-week treatment with a face cream containing Anacyclus pyrethrum extracts showed potential to protect skin from damage.[19]

    References

    1. ^Jawhari FZ, Moussaoui AEL, Bourhia M, Imtara H, Saghrouchni H, Ammor K, Ouassou H, Elamine Y, Ullah R, Ezzeldin E, Mostafa GAE, Bari Avar. (L.) and var. (Ball) Maire: Correlation between Total Phenolic and Flavonoid Contents with Antioxidant and Antimicrobial Activities of Chemically Characterized Extracts.Plants (Basel).(2021-Jan-13)
    2. ^Jalayer-Naderi N, Niakan M, Khodadadi E, Mohamadi-Motlagh MThe antibacterial activity of methanolic and extract on .Iran J Microbiol.(2016-Dec)
    3. ^Manouze H, Bouchatta O, Gadhi AC, Bennis M, Sokar Z, Ba-M'hamed SAnti-inflammatory, Antinociceptive, and Antioxidant Activities of Methanol and Aqueous Extracts of Roots.Front Pharmacol.(2017)
    4. ^Alliouche Kerboua K, Benosmane L, Namoune S, Ouled-Diaf K, Ghaliaoui N, Bendjeddou DAnti-inflammatory and antioxidant activity of the hot water-soluble polysaccharides from Anacyclus pyrethrum (L.) Lag. roots.J Ethnopharmacol.(2021-Dec-05)
    5. ^Fatima Zahra Jawhari, Abdelfattah El Moussaoui, Mohammed Bourhia, Hamada Imtara, Hamza Mechchate, Imane Es-Safi, Riaz Ullah, Essam Ezzeldin, Gamal A Mostafa, Andriy Grafov, Samir Ibenmoussa, Dalila Bousta, Amina BariAnacyclus pyrethrum (L): Chemical Composition, Analgesic, Anti-Inflammatory, and Wound Healing PropertiesMolecules.(2020 Nov 23)
    6. ^Yousaf F, Shahid M, Riaz M, Atta A, Fatima HImmunomodulatory potential of Anacyclus pyrethrum (L.) and Mucuna pruriens (L.) In male albino rats.J Biol Regul Homeost Agents.(2017)
    7. ^Sharma V, Thakur M, Chauhan NS, Dixit VKImmunomodulatory activity of petroleum ether extract of Anacyclus pyrethrum.Pharm Biol.(2010-Nov)
    8. ^Bendjeddou D, Lalaoui K, Satta DImmunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis.J Ethnopharmacol.(2003-Oct)
    9. ^Muralikrishnan K, Asokan S, Geetha Priya PR, Zameer Ahmed KS, Ayyappadasan GComparative Evaluation of the Local Anesthetic Activity of Root Extract of and its Interaction at the Site of Injection in Guinea Pigs.Anesth Essays Res.(2017)
    10. ^Manouze H, Ghestem A, Bennis M, Sokar Z, Benoliel JJ, Becker C, Ba-M'hamed S, Bernard CAntiseizure effects of Anacyclus pyrethrum in socially isolated rats with and without a positive handling strategy.Epilepsia.(2021-Oct)
    11. ^Manouze H, Bouchatta O, Bennis M, Sokar Z, Ba-M'hamed SAnticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice.Epilepsy Res.(2019-Dec)
    12. ^Pahuja M, Mehla J, Reeta KH, Joshi S, Gupta YKRoot extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals.Epilepsy Res.(2012-Feb)
    13. ^Pahuja M, Mehla J, Reeta KH, Tripathi M, Gupta YKEffect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice.Neurochem Res.(2013-Mar)
    14. ^Sujith K et al.Memory-enhancing activity of Anacyclus pyrethrum in albino Wistar rats.Asian Pac J Trop Dis.(2012)
    15. ^Haghmorad D, Mahmoudi MB, Haghighi P, Alidadiani P, Shahvazian E, Tavasolian P, Hosseini M, Mahmoudi MImprovement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats.Int Braz J Urol.(2019)
    16. ^Sharma V, Boonen J, Spiegeleer BD, Dixit VKAndrogenic and spermatogenic activity of alkylamide-rich ethanol solution extract of Anacyclus pyrethrum DC.Phytother Res.(2013-Jan)
    17. ^Sharma V, Thakur M, Chauhan NS, Dixit VKEffects of petroleum ether extract of Anacyclus pyrethrum DC. on sexual behavior in male rats.Zhong Xi Yi Jie He Xue Bao.(2010-Aug)
    18. ^Sharma V et al.Evaluation of the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus Pyrethrum DC in Male Rats.Sci Pharm.(2009)
    19. ^Muhammad Saleem Qureshi, Qazi Adnan Jamil, Naveed Akhtar, Naheed AkhtarFormulation and characterization of Anacyclus Pyrethrum Emulgels and its in vitro and in vivo evaluation as cosmeceutical productJ Cosmet Dermatol.(2022 Dec)