The word “aloe” is derived from the Arabic word alloeh, which translates to “bitter and shiny substance”, while “vera” comes from the Latin word for truth.<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>
Historical use of Aloe vera dates back to 2100 BC, as evidenced by its mention on a Mesopotamian clay tablet. Aloe vera was also documented in a papyrus discovered in a sarcophagus near Thebes (Egypt), and it was recognized for its therapeutic properties by ancient physicians such as Dioscorides, Pliny the Elder, and Galen. 
Though there isn't definitive historical evidence, it's believed that Egyptian queens Nefertiti and Cleopatra incorporated Aloe vera into their beauty regimens. Another legend says that Alexander the Great (333 BC) was encouraged by Aristotle to conquer Socotra Island, in the Indian Ocean, to obtain its abundant, medicinal aloe.<a href="#ref-17" id="ref-link-17" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Atherton P. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/9776900" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: magic or medicine?
&lt;/a&gt;&lt;/p&gt;Nurs Stand (1998)&lt;/div&gt;'>[17]</a><a href="#ref-18" id="ref-link-18" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Crosswhite, F and Crosswhite, S. Aloe vera, Plant Symbolism and the Threshing Floor
&lt;/p&gt;Desert Plants (1984)&lt;/div&gt;'>[18]</a>

What is the history of Aloe vera?

Aloe is a genus of succulent perennial plants in the Liliaceae family characterized by fleshy green leaves arranged in a rosette formation along the stem. Aloe vera (synonym: Aloe barbadensis Mill.) is a species of the genus Aloe, alongside other species such as Aloe ferox (bitter aloe) and Aloe arborescens.<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>
Commercially, Aloe vera is available in three main forms: Aloe vera gel, Aloe vera latex, and Aloe vera juice (or whole leaf extract). The latter of these contains both the gel and the latex and should not be confused with Aloe vera beverages sold in stores, which typically contain Aloe vera diluted in water or juice (e.g., grapefruit).<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a> While it is widely recognized for its topical application to alleviate pain from burns, Aloe vera is also used in cosmetic, food, and pharmaceutical products.<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>

What is Aloe vera?

One small 2005 study found that Aloe vera gel could potentially increase the absorption and prolong the presence of both <a href="/supplements/vitamin-c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Vitamin C&lt;/h6&gt;&lt;p&gt;Vitamin C, or ascorbic acid, is an essential vitamin and a very popular supplement due to its antioxidant properties, safety profile, and low price. Many people supplement with vitamin C because it is believed to reduce symptoms of the common cold.&lt;/p&gt;&lt;/div&gt;">vitamin C</a> and <a href="/supplements/vitamin-e/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Vitamin E&lt;/h6&gt;&lt;p&gt;Vitamin E is a group of eight different compounds which, collectively, help support antioxidation in the body. Benefits of high doses have uncertain safety, and lower doses seem effective in boosting immunity in the elderly.&lt;/p&gt;&lt;/div&gt;">vitamin E</a> in the body.<a href="#ref-19" id="ref-link-19" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Vinson JA, Al Kharrat H, Andreoli L. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/16323295" target="\_blank" rel="noopener noreferrer"&gt;Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.
&lt;/a&gt;&lt;/p&gt;Phytomedicine (2005-Nov)&lt;/div&gt;'>[19]</a> However, the specific dosage of Aloe vera gel used and the concentrations of vitamin C and E within the gel were not specified in the study, which could affect the outcomes. Additionally, it's noteworthy that the research was funded by the International Aloe Science Council, raising the possibility of bias in the findings.

Can aloe vera be taken with other supplements?

The potential benefits of Aloe vera in preventing or improving <a href="/conditions/type-2-diabetes/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Type 2 Diabetes&lt;/h6&gt;&lt;p&gt;Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.&lt;/p&gt;&lt;/div&gt;">type 2 diabetes</a> or <a href="/conditions/prediabetes/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Prediabetes&lt;/h6&gt;&lt;p&gt;Prediabetes is the intermediate stage between healthy blood glucose levels and diabetes. It is associated with an increased risk of cardiovascular disease and type 2 diabetes. Weight loss induced by lifestyle intervention is the primary treatment and is very effective.&lt;/p&gt;&lt;/div&gt;">prediabetes</a> remain inconclusive due to the varying methodologies and quality of studies on this topic.
In one <a href="/glossary/meta-analysis/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Meta-analysis&lt;/h6&gt;&lt;p&gt;A meta-analysis is usually produced as part of a systematic review. It combines the numerical results from several studies into an average number. Studies that differ too much in design cannot be properly meta-analyzed.&lt;/p&gt;&lt;/div&gt;">meta-analysis</a>, people with prediabetes taking Aloe vera showed a significant reduction in <a href="/outcomes/fasting-glucose/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Fasting Glucose&lt;/h6&gt;&lt;p&gt;Fasting glucose is the concentration of glucose in the blood after a period of fasting, typically overnight.&lt;/p&gt;&lt;/div&gt;">fasting blood glucose</a> (FBG) levels, compared to a <a href="/glossary/control/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Control&lt;/h6&gt;&lt;p&gt;A control provides a comparator that allows determination of the safety and effectiveness of a treatment. For example, a control group is a group of study participants that does not receive the experimental treatment. Instead, participants in the control group may receive a standard treatment, a glossary:placebo, or nothing, while keeping all other aspects of the study the same for the control group as for the group receiving the experimental treatment.&lt;/p&gt;&lt;/div&gt;">control</a>. However, the effect in people with type 2 diabetes was weak and not confirmed by sensitivity analyses. On the other hand, <a href="/outcomes/hba1c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;HbA1c&lt;/h6&gt;&lt;p&gt;HbA1c (glycated hemoglobin) is a biomarker of glucose metabolism — it reflects glucose levels over months. Higher HbA1c is associated with more disease progression and comorbidities in states of insulin resistance or diabetes.&lt;/p&gt;&lt;/div&gt;">HbA1c</a> (glycated hemoglobin) levels were significantly decreased by Aloe vera supplementation in people with type 2 diabetes but not in people with prediabetes.<a href="#ref-1" id="ref-link-1" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;N Suksomboon, N Poolsup, S Punthanitisarn. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/27009750" target="\_blank" rel="noopener noreferrer"&gt;Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis
&lt;/a&gt;&lt;/p&gt;J Clin Pharm Ther (2016 Apr)&lt;/div&gt;'>[1]</a> It’s important to note that some studies included participants who were using antihyperglycemic medications (medication to lower blood sugar levels) and/or non-pharmacologic interventions other than aloe, making it challenging to attribute the observed effects solely to Aloe vera.
Another meta-analysis, assessing the effect of supplementation with Aloe vera in people with prediabetes or early non-treated type 2 diabetes who also had <a href="/conditions/overweight/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Overweight&lt;/h6&gt;&lt;p&gt;Overweight is characterized as having a &lt;em&gt;body mass index&lt;/em&gt; bmi|(BMI) of 25 to 29.9. Having overweight is associated with increased risk of conditions such as cardiovascular disease. However, this may not be the case in people with increased lean mass (e.g., athletes or weight lifters).&lt;/p&gt;&lt;/div&gt;">overweight</a> or <a href="/conditions/obesity/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Obesity&lt;/h6&gt;&lt;p&gt;Obesity is a condition of excessive body fat that increases the risk for other conditions such as diabetes and heart disease. Fat is how the body stores extra calories that were eaten but not used. Obesity treatment usually involves restricting the calories eaten or creating negative calorie balance.&lt;/p&gt;&lt;/div&gt;">obesity</a>, showed a reduction in both FBG and HbA1c levels compared to a placebo, although there was no effect on <a href="/outcomes/insulin/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Insulin&lt;/h6&gt;&lt;p&gt;Insulin is a hormone that rises when blood glucose rises. It lowers blood glucose by telling cells to absorb and use it. If your cells’ insulin sensitivity is low, they won’t absorb enough glucose — you have insulin resistance, which can lead to type 2 diabetes.&lt;/p&gt;&lt;/div&gt;">insulin</a> levels. Additionally, Aloe vera supplementation led to improvements in lipid profiles, including decreased <a href="/outcomes/triglycerides/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Triglycerides&lt;/h6&gt;&lt;p&gt;Triglycerides refers to the fatty acids in your blood. They can be used for energy or stored into fat cells (i.e., body fat). Abnormal triglycerides raise the risk of cardiovascular disease (CVD).&lt;/p&gt;&lt;/div&gt;">triglycerides</a>, <a href="/outcomes/total-cholesterol/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Total cholesterol&lt;/h6&gt;&lt;p&gt;Total cholesterol refers to all the cholesterol in your blood (HDL-C and LDL-C). It is distinct from triglycerides.&lt;/p&gt;&lt;/div&gt;">total cholesterol</a> (TC), and low-density lipoprotein (<a href="/outcomes/ldl-c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Low-density lipoprotein (LDL)&lt;/h6&gt;&lt;p&gt;LDL carries cholesterol from the liver to other parts of the body. Because higher levels of LDL cholesterol (LDL-C) tend to increase the risk of cardiovascular disease (CVD), LDL-C is often called the “bad cholesterol” (as opposed to HDL-C) — but the reality is more complex.&lt;/p&gt;&lt;/div&gt;">LDL</a>) levels, as well as an increase in high-density lipoprotein (<a href="/outcomes/hdl/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;High-density lipoprotein (HDL)&lt;/h6&gt;&lt;p&gt;&lt;em&gt;High-density lipoprotein&lt;/em&gt; (HDL) is a particle that carries cholesterol from your blood to your liver. Low levels of &lt;em&gt;HDL cholesterol&lt;/em&gt; (HDL-C) are associated with a higher risk of &lt;em&gt;cardiovascular disease&lt;/em&gt; (CVD), which is why HDL-C is often called the “good cholesterol” (as opposed to LDL-C) — but the reality is more complex.&lt;/p&gt;&lt;/div&gt;">HDL</a>) levels compared to a placebo.<a href="#ref-2" id="ref-link-2" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Yiyi Zhang, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/27347994" target="\_blank" rel="noopener noreferrer"&gt;Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
&lt;/a&gt;&lt;/p&gt;Nutrients (2016 Jun 23)&lt;/div&gt;'>[2]</a> Similar results were observed in another meta-analysis.<a href="#ref-21" id="ref-link-21" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Dick WR, Fletcher EA, Shah SA. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/27152917" target="\_blank" rel="noopener noreferrer"&gt;Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis.
&lt;/a&gt;&lt;/p&gt;J Altern Complement Med (2016-Jun)&lt;/div&gt;'>[21]</a>

Can Aloe vera be beneficial for diabetes or prediabetes?

Aloe vera is commercially sold to treat burns and various skin conditions. While the evidence supporting its effectiveness is not robust, one <a href="/glossary/meta-analysis/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Meta-analysis&lt;/h6&gt;&lt;p&gt;A meta-analysis is usually produced as part of a systematic review. It combines the numerical results from several studies into an average number. Studies that differ too much in design cannot be properly meta-analyzed.&lt;/p&gt;&lt;/div&gt;">meta-analysis</a> suggested that burns treated with Aloe vera may heal more quickly than those given standard treatment.<a href="#ref-4" id="ref-link-4" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Sharma S, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/36264753" target="\_blank" rel="noopener noreferrer"&gt;Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review.
&lt;/a&gt;&lt;/p&gt;Adv Skin Wound Care (2022-Nov-01)&lt;/div&gt;'>[4]</a> Similarly, some studies indicate that Aloe vera may reduce the severity of <a href="/outcomes/psoriasis-symptoms/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Psoriasis Symptoms&lt;/h6&gt;&lt;p&gt;Psoriasis is a chronic skin disease that causes patches of thick, red, scaly skin on various parts of the body. Its cause is unknown and symptoms tend to wax and wane over time.&lt;/p&gt;&lt;/div&gt;">psoriasis symptoms</a> in individuals with mucocutaneous conditions.<a href="#ref-5" id="ref-link-5" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Gok Metin Z, Helvaci A, Gulbahar Eren M. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/33336470" target="\_blank" rel="noopener noreferrer"&gt;Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.
&lt;/a&gt;&lt;/p&gt;J Adv Nurs (2021-Mar)&lt;/div&gt;'>[5]</a> However, Aloe vera does not seem to be effective in improving symptoms of radiation dermatitis (RD), a common side effect of radiotherapy.<a href="#ref-6" id="ref-link-6" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Robijns J, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/36859690" target="\_blank" rel="noopener noreferrer"&gt;Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.
&lt;/a&gt;&lt;/p&gt;Support Care Cancer (2023-Mar-02)&lt;/div&gt;'>[6]</a>
Topical application of Aloe vera may also be beneficial for nipple pain and irritation in <a href="/other/breastfeeding/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Breastfeeding&lt;/h6&gt;&lt;p&gt;Breastfeeding — also referred to as nursing — is the process of feeding breast milk to a child. This page refers to breastfeeding as an intervention (e.g., compared to infant formula) — please visit our lactation|lactation page to learn more about ways to improve breast milk production.&lt;/p&gt;&lt;/div&gt;">breastfeeding</a> women,<a href="#ref-7" id="ref-link-7" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Maleki A, Youseflu S. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/36388847" target="\_blank" rel="noopener noreferrer"&gt;The Effectiveness of Aloe Vera on Relief of Irritation and Nipple Pain in Lactating Women: Systematic Review and Meta-Analysis.
&lt;/a&gt;&lt;/p&gt;Obstet Gynecol Int (2022)&lt;/div&gt;'>[7]</a> although further research with stronger methodologies is needed to confirm these findings.
Additionally, Aloe vera may have benefits for oral health. Topical oral applications of Aloe vera in mouthwash or gels have been shown to reduce plaque formation, gum inflammation, and bleeding in people with periodontal disease (gum disease) to a greater degree than commonly used preparations (e.g., fluoride‑containing triclosan, chlorhexidine).<a href="#ref-8" id="ref-link-8" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Ashwini Narendra Jadhav, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/34667378" target="\_blank" rel="noopener noreferrer"&gt;Effect of Aloe vera as a local drug delivery agent in the management of periodontal diseases: A systematic review and meta-analysis
&lt;/a&gt;&lt;/p&gt;J Indian Soc Periodontol (Sep-Oct 2021)&lt;/div&gt;'>[8]</a> Furthermore, one meta-analysis found that, for the treatment of oral ulcers, various topical preparations of Aloe vera gel had better therapeutic effect and shorter therapy duration than a <a href="/glossary/control/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Control&lt;/h6&gt;&lt;p&gt;A control provides a comparator that allows determination of the safety and effectiveness of a treatment. For example, a control group is a group of study participants that does not receive the experimental treatment. Instead, participants in the control group may receive a standard treatment, a glossary:placebo, or nothing, while keeping all other aspects of the study the same for the control group as for the group receiving the experimental treatment.&lt;/p&gt;&lt;/div&gt;">control</a>, although their effects on ulcer size and subjective pain did not differ significantly from the control.<a href="#ref-9" id="ref-link-9" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Zou H, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/36504087" target="\_blank" rel="noopener noreferrer"&gt;Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
&lt;/a&gt;&lt;/p&gt;Oral Health Prev Dent (2022-Dec-12)&lt;/div&gt;'>[9]</a>
Finally, some Aloe vera preparations can also be taken orally, and one meta-analysis found that Aloe vera may be effective in improving symptoms of <a href="/conditions/irritable-bowel-syndrome/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Irritable Bowel Syndrome&lt;/h6&gt;&lt;p&gt;&lt;em&gt;Irritable Bowel Syndrome&lt;/em&gt; (IBS) is a common functional disorder of the large intestine characterized by long-term changes in bowel habits (e.g., frequent diarrhea or constipation) and abdominal pain. The exact causes are unknown, but research suggests that multiple factors — such as the gut-brain axis, abnormal muscular contractions, and gut microbes — could play a role in the disease. IBS can be managed with dietary modifications, psychotherapy, supplements, and prescription medications.&lt;/p&gt;&lt;/div&gt;">irritable bowel syndrome</a> (IBS), although the evidence is not strong.<a href="#ref-10" id="ref-link-10" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Hong SW, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/30153721" target="\_blank" rel="noopener noreferrer"&gt;Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.
&lt;/a&gt;&lt;/p&gt;J Neurogastroenterol Motil (2018-Oct-01)&lt;/div&gt;'>[10]</a>

What are Aloe vera’s main benefits?

Consumption of Aloe vera latex is not recommended during pregnancy. This is mainly due to its anthraquinone component, which, in addition to its laxative properties, may stimulate uterine contractions, potentially leading to premature labor or miscarriage.<a href="#ref-20" id="ref-link-20" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Cosmetic Ingredient Review Expert Panel. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/17613130" target="\_blank" rel="noopener noreferrer"&gt;Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.
&lt;/a&gt;&lt;/p&gt;Int J Toxicol (2007)&lt;/div&gt;'>[20]</a><a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a> One case study reported adverse effects in a fetus when the mother consumed Aloe vera, including intestinal peristalsis, the release of meconium in the uterus, and kidney damage.<a href="#ref-20" id="ref-link-20" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Cosmetic Ingredient Review Expert Panel. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/17613130" target="\_blank" rel="noopener noreferrer"&gt;Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.
&lt;/a&gt;&lt;/p&gt;Int J Toxicol (2007)&lt;/div&gt;'>[20]</a>
Additionally, the anthraquinone component of Aloe vera latex and juice may be excreted into breast milk, potentially causing diarrhea in nursing infants. <a href="#ref-20" id="ref-link-20" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Cosmetic Ingredient Review Expert Panel. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/17613130" target="\_blank" rel="noopener noreferrer"&gt;Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.
&lt;/a&gt;&lt;/p&gt;Int J Toxicol (2007)&lt;/div&gt;'>[20]</a>

Is Aloe vera safe during pregnancy and breastfeeding?

Aloe vera topical gel is generally well-tolerated, but there have been reports of hypersensitive skin reactions.<a href="#ref-5" id="ref-link-5" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Gok Metin Z, Helvaci A, Gulbahar Eren M. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/33336470" target="\_blank" rel="noopener noreferrer"&gt;Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.
&lt;/a&gt;&lt;/p&gt;J Adv Nurs (2021-Mar)&lt;/div&gt;'>[5]</a> 
Additionally, Aloe vera latex, a yellow-brownish liquid extracted from the skin of the plant's leaves and traditionally used as a laxative, and Aloe vera whole leaf extract, which contains the latex, may pose a risk of toxicity due to the latex’s high content of anthranoids.<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a><a href="#ref-1" id="ref-link-1" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;N Suksomboon, N Poolsup, S Punthanitisarn. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/27009750" target="\_blank" rel="noopener noreferrer"&gt;Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis
&lt;/a&gt;&lt;/p&gt;J Clin Pharm Ther (2016 Apr)&lt;/div&gt;'>[1]</a>
Topical and oral use of Aloe vera can also theoretically cause skin irritation, <a href="/conditions/urticaria/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Urticaria&lt;/h6&gt;&lt;p&gt;Urticaria — also known as hives, nettle rash, or wheals — can be an acute or chronic condition. Acute urticaria typically results from exposure to an allergen or infection and lasts less than 6 weeks, whereas chronic urticaria lasts longer and seems to be related to autoimmune dysfunction.&lt;/p&gt;&lt;/div&gt;">urticaria</a>, cramping, and <a href="/outcomes/diarrhea-symptoms/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Diarrhea Symptoms&lt;/h6&gt;&lt;p&gt;Diarrhea refers to loose, watery stools that may be caused by a virus, contaminated food, or disorders such as inflammatory bowel disease.&lt;/p&gt;&lt;/div&gt;">diarrhea</a> in people who are allergic to other plants in the same family (e.g., onion).<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>
Regarding interactions with medications, there is evidence of a potential herb-drug interaction between Aloe vera whole leaf extract and sevoflurane, a general anesthetic.<a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>
Finally, Aloe vera has been associated with cases of acute hepatitis (liver inflammation). This side effect typically occurs within an oral dosage range of 250–500 mg per day, and while the effects appear reversible, the exact mechanism of toxicity is not fully understood.<a href="#ref-11" id="ref-link-11" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Bottenberg MM, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/17726067" target="\_blank" rel="noopener noreferrer"&gt;Oral aloe vera-induced hepatitis.
&lt;/a&gt;&lt;/p&gt;Ann Pharmacother (2007-Oct)&lt;/div&gt;'>[11]</a><a href="#ref-12" id="ref-link-12" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Yang HN, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/20191055" target="\_blank" rel="noopener noreferrer"&gt;Aloe-induced toxic hepatitis.
&lt;/a&gt;&lt;/p&gt;J Korean Med Sci (2010-Mar)&lt;/div&gt;'>[12]</a><a href="#ref-3" id="ref-link-3" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Guo X, Mei N. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/26986231" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: A review of toxicity and adverse clinical effects.
&lt;/a&gt;&lt;/p&gt;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2016-Apr-02)&lt;/div&gt;'>[3]</a>

What are Aloe vera’s main drawbacks?

Aloe vera contains more than 75 bioactive compounds, including vitamins, enzymes, minerals, anthraquinones, sugars, hormones, and fatty acids, among others.<a href="#ref-13" id="ref-link-13" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Sánchez M, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/32183224" target="\_blank" rel="noopener noreferrer"&gt;Pharmacological Update Properties of and its Major Active Constituents.
&lt;/a&gt;&lt;/p&gt;Molecules (2020-Mar-13)&lt;/div&gt;'>[13]</a> Therefore, several mechanisms of action have been proposed for the effects of Aloe vera.
<a href="/glossary/in-vitro-study/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;In Vitro Study&lt;/h6&gt;&lt;p&gt;&lt;em&gt;In vitro&lt;/em&gt; (Latin for “within the glass”) refers to studies that are performed outside of a living organism. In scientific research, this often involves performing experiments on bacterial, animal, or human cells growing in lab culture dishes.&lt;/p&gt;&lt;/div&gt;">In vitro</a> studies suggest that aloesin, aloin, and emodin are the main compounds responsible for the skin-protective properties of Aloe vera, thanks to their antioxidant and anti-inflammatory mechanisms.<a href="#ref-13" id="ref-link-13" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Sánchez M, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/32183224" target="\_blank" rel="noopener noreferrer"&gt;Pharmacological Update Properties of and its Major Active Constituents.
&lt;/a&gt;&lt;/p&gt;Molecules (2020-Mar-13)&lt;/div&gt;'>[13]</a> Magnesium lactate present in Aloe vera may also contribute to alleviating skin <a href="/outcomes/itching/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Itching&lt;/h6&gt;&lt;p&gt;Itching, also known as pruritis, is an uncomfortable physical sensation that drives an urge to scratch the itchy area. It is multifactorial; causes include skin conditions, insects, liver disease, medications, pregnancy, nerve damage, cancer, and more.&lt;/p&gt;&lt;/div&gt;">itching</a> and irritation by reducing histamine production.<a href="#ref-14" id="ref-link-14" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Bunyapraphatsara N, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/23194624" target="\_blank" rel="noopener noreferrer"&gt;The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice.
&lt;/a&gt;&lt;/p&gt;Phytomedicine (1996-Jan)&lt;/div&gt;'>[14]</a> Additionally, the glycoprotein fraction of Aloe vera appears to inhibit thromboxanes and promote type-III <a href="/supplements/type-ii-collagen/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Type-II Collagen&lt;/h6&gt;&lt;p&gt;Type II collagen (CII) is a protein and component of joint cartilage. Oral ingestion of CII in its undenatured form may reduce autoimmunity to the body's own CII, resulting in less joint inflammation in instances of osteoarthritis and rheumatism.&lt;/p&gt;&lt;/div&gt;">collagen</a> production, which facilitates skin healing.<a href="#ref-15" id="ref-link-15" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Levin NJ, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/36337821" target="\_blank" rel="noopener noreferrer"&gt;A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera.
&lt;/a&gt;&lt;/p&gt;Cureus (2022-Oct)&lt;/div&gt;'>[15]</a>
Another essential constituent of Aloe vera, acemannan, is a mucopolysaccharide that exhibits anti-inflammatory and gastroprotective properties.<a href="#ref-13" id="ref-link-13" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Sánchez M, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/32183224" target="\_blank" rel="noopener noreferrer"&gt;Pharmacological Update Properties of and its Major Active Constituents.
&lt;/a&gt;&lt;/p&gt;Molecules (2020-Mar-13)&lt;/div&gt;'>[13]</a> Furthermore, anthraquinones found in Aloe vera latex confer its laxative effect by increasing intestinal water content, stimulating mucus secretion, and enhancing intestinal peristalsis.<a href="#ref-16" id="ref-link-16" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Surjushe A, Vasani R, Saple DG. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/19882025" target="\_blank" rel="noopener noreferrer"&gt;Aloe vera: a short review.
&lt;/a&gt;&lt;/p&gt;Indian J Dermatol (2008)&lt;/div&gt;'>[16]</a><a href="#ref-10" id="ref-link-10" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;Hong SW, et al. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/30153721" target="\_blank" rel="noopener noreferrer"&gt;Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.
&lt;/a&gt;&lt;/p&gt;J Neurogastroenterol Motil (2018-Oct-01)&lt;/div&gt;'>[10]</a>
Regarding its hypoglycemic effect, Aloe vera may work by reducing glucose absorption in the gastrointestinal tract after food, stimulating glucose catabolism, and suppressing gluconeogenesis (glucose production). Activation of <a href="/glossary/ampk/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;AMPK&lt;/h6&gt;&lt;p&gt;&lt;em&gt;Adenosine monophosphate-activated protein kinase&lt;/em&gt; (AMPK) is an enzyme that helps regulate energy in the body.&lt;/p&gt;&lt;/div&gt;">AMPK</a>, akin to the mechanism of action of metformin (a medication for type 2 diabetes), is also proposed as a possible pathway for the hypoglycemic effects of Aloe vera.<a href="#ref-1" id="ref-link-1" class="ref-link popover" data-tooltip='&lt;div&gt;&lt;p class="mb-3"&gt;N Suksomboon, N Poolsup, S Punthanitisarn. &lt;a href="https://pubmed.ncbi.nlm.nih.gov/27009750" target="\_blank" rel="noopener noreferrer"&gt;Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis
&lt;/a&gt;&lt;/p&gt;J Clin Pharm Ther (2016 Apr)&lt;/div&gt;'>[1]</a>

How does Aloe vera work?

Aloe Vera

Skin, Hair, & Nails

Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis

Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Aloe vera: A review of toxicity and adverse clinical effects.

Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review.

Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.

Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.

The Effectiveness of Aloe Vera on Relief of Irritation and Nipple Pain in Lactating Women: Systematic Review and Meta-Analysis.

Effect of Aloe vera as a local drug delivery agent in the management of periodontal diseases: A systematic review and meta-analysis

Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.

Oral aloe vera-induced hepatitis.

Aloe-induced toxic hepatitis.

Pharmacological Update Properties of  and its Major Active Constituents.

The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice.

A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera.

Aloe vera: a short review.

Aloe vera: magic or medicine?

Aloe vera, Plant Symbolism and the Threshing Floor

Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.

Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.

Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis.

Kamal Patel

Canker Sores

Canker Sores Symptoms

Diabetes & Blood Sugar

Prediabetes

Fasting Glucose

HbA1c

High-density lipoprotein (HDL)

Low-density lipoprotein (LDL)

Total cholesterol

Triglycerides

Insulin

General Oral Health

Dental Health Metrics

Pain

Irritable Bowel Syndrome

Irritable Bowel Syndrome Symptoms

Skin, Hair & Nails

Psoriasis

Psoriasis Symptoms

Type 2 Diabetes

Gum Health

Lactation

Nipple Cracks

Pain Relief

Skin Health

Gingivitis

Periodontitis

Radiation Therapy Side-Effects

Dermatitis Risk

Erythema

Itching

Wounds and burns

Wound Healing

Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis

Acemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous Ulceration

 Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.

The word “aloe” is derived from the Arabic word alloeh, which translates to “bitter and shiny substance”, while “vera” comes from the Latin word for truth.[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]
Historical use of Aloe vera dates back to 2100 BC, as evidenced by its mention on a Mesopotamian clay tablet. Aloe vera was also documented in a papyrus discovered in a sarcophagus near Thebes (Egypt), and it was recognized for its therapeutic properties by ancient physicians such as Dioscorides, Pliny the Elder, and Galen. 
Though there isn't definitive historical evidence, it's believed that Egyptian queens Nefertiti and Cleopatra incorporated Aloe vera into their beauty regimens. Another legend says that Alexander the Great (333 BC) was encouraged by Aristotle to conquer Socotra Island, in the Indian Ocean, to obtain its abundant, medicinal aloe.[reference|url=https://pubmed.ncbi.nlm.nih.gov/9776900|title=Aloe vera: magic or medicine?|published=1998|authors=Atherton P|journal=Nurs Stand|][reference|title=Aloe vera, Plant Symbolism and the Threshing Floor|authors=Crosswhite, F and Crosswhite, S|journal=Desert Plants|published=1984]

Aloe is a genus of succulent perennial plants in the Liliaceae family characterized by fleshy green leaves arranged in a rosette formation along the stem. Aloe vera (synonym: Aloe barbadensis Mill.) is a species of the genus Aloe, alongside other species such as Aloe ferox (bitter aloe) and Aloe arborescens.[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]
Commercially, Aloe vera is available in three main forms: Aloe vera gel, Aloe vera latex, and Aloe vera juice (or whole leaf extract). The latter of these contains both the gel and the latex and should not be confused with Aloe vera beverages sold in stores, which typically contain Aloe vera diluted in water or juice (e.g., grapefruit).[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|] While it is widely recognized for its topical application to alleviate pain from burns, Aloe vera is also used in cosmetic, food, and pharmaceutical products.[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]

One small 2005 study found that Aloe vera gel could potentially increase the absorption and prolong the presence of both <a href="/supplements/vitamin-c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Vitamin C&lt;/h6&gt;&lt;p&gt;Vitamin C, or ascorbic acid, is an essential vitamin and a very popular supplement due to its antioxidant properties, safety profile, and low price. Many people supplement with vitamin C because it is believed to reduce symptoms of the common cold.&lt;/p&gt;&lt;/div&gt;">vitamin C</a> and <a href="/supplements/vitamin-e/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Vitamin E&lt;/h6&gt;&lt;p&gt;Vitamin E is a group of eight different compounds which, collectively, help support antioxidation in the body. Benefits of high doses have uncertain safety, and lower doses seem effective in boosting immunity in the elderly.&lt;/p&gt;&lt;/div&gt;">vitamin E</a> in the body.[reference|url=https://pubmed.ncbi.nlm.nih.gov/16323295|title=Effect of Aloe vera preparations on the human bioavailability of vitamins C and E.|published=2005-Nov|authors=Vinson JA, Al Kharrat H, Andreoli L|journal=Phytomedicine|] However, the specific dosage of Aloe vera gel used and the concentrations of vitamin C and E within the gel were not specified in the study, which could affect the outcomes. Additionally, it's noteworthy that the research was funded by the International Aloe Science Council, raising the possibility of bias in the findings.

The potential benefits of Aloe vera in preventing or improving <a href="/conditions/type-2-diabetes/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Type 2 Diabetes&lt;/h6&gt;&lt;p&gt;Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.&lt;/p&gt;&lt;/div&gt;">type 2 diabetes</a> or <a href="/conditions/prediabetes/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Prediabetes&lt;/h6&gt;&lt;p&gt;Prediabetes is the intermediate stage between healthy blood glucose levels and diabetes. It is associated with an increased risk of cardiovascular disease and type 2 diabetes. Weight loss induced by lifestyle intervention is the primary treatment and is very effective.&lt;/p&gt;&lt;/div&gt;">prediabetes</a> remain inconclusive due to the varying methodologies and quality of studies on this topic.
In one <a href="/glossary/meta-analysis/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Meta-analysis&lt;/h6&gt;&lt;p&gt;A meta-analysis is usually produced as part of a systematic review. It combines the numerical results from several studies into an average number. Studies that differ too much in design cannot be properly meta-analyzed.&lt;/p&gt;&lt;/div&gt;">meta-analysis</a>, people with prediabetes taking Aloe vera showed a significant reduction in <a href="/outcomes/fasting-glucose/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Fasting Glucose&lt;/h6&gt;&lt;p&gt;Fasting glucose is the concentration of glucose in the blood after a period of fasting, typically overnight.&lt;/p&gt;&lt;/div&gt;">fasting blood glucose</a> (FBG) levels, compared to a <a href="/glossary/control/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Control&lt;/h6&gt;&lt;p&gt;A control provides a comparator that allows determination of the safety and effectiveness of a treatment. For example, a control group is a group of study participants that does not receive the experimental treatment. Instead, participants in the control group may receive a standard treatment, a glossary:placebo, or nothing, while keeping all other aspects of the study the same for the control group as for the group receiving the experimental treatment.&lt;/p&gt;&lt;/div&gt;">control</a>. However, the effect in people with type 2 diabetes was weak and not confirmed by sensitivity analyses. On the other hand, <a href="/outcomes/hba1c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;HbA1c&lt;/h6&gt;&lt;p&gt;HbA1c (glycated hemoglobin) is a biomarker of glucose metabolism — it reflects glucose levels over months. Higher HbA1c is associated with more disease progression and comorbidities in states of insulin resistance or diabetes.&lt;/p&gt;&lt;/div&gt;">HbA1c</a> (glycated hemoglobin) levels were significantly decreased by Aloe vera supplementation in people with type 2 diabetes but not in people with prediabetes.[reference|url=https://pubmed.ncbi.nlm.nih.gov/27009750|title=Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis|published=2016 Apr|authors=N Suksomboon, N Poolsup, S Punthanitisarn|journal=J Clin Pharm Ther|] It’s important to note that some studies included participants who were using antihyperglycemic medications (medication to lower blood sugar levels) and/or non-pharmacologic interventions other than aloe, making it challenging to attribute the observed effects solely to Aloe vera.
Another meta-analysis, assessing the effect of supplementation with Aloe vera in people with prediabetes or early non-treated type 2 diabetes who also had <a href="/conditions/overweight/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Overweight&lt;/h6&gt;&lt;p&gt;Overweight is characterized as having a &lt;em&gt;body mass index&lt;/em&gt; bmi|(BMI) of 25 to 29.9. Having overweight is associated with increased risk of conditions such as cardiovascular disease. However, this may not be the case in people with increased lean mass (e.g., athletes or weight lifters).&lt;/p&gt;&lt;/div&gt;">overweight</a> or <a href="/conditions/obesity/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Obesity&lt;/h6&gt;&lt;p&gt;Obesity is a condition of excessive body fat that increases the risk for other conditions such as diabetes and heart disease. Fat is how the body stores extra calories that were eaten but not used. Obesity treatment usually involves restricting the calories eaten or creating negative calorie balance.&lt;/p&gt;&lt;/div&gt;">obesity</a>, showed a reduction in both FBG and HbA1c levels compared to a placebo, although there was no effect on <a href="/outcomes/insulin/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Insulin&lt;/h6&gt;&lt;p&gt;Insulin is a hormone that rises when blood glucose rises. It lowers blood glucose by telling cells to absorb and use it. If your cells’ insulin sensitivity is low, they won’t absorb enough glucose — you have insulin resistance, which can lead to type 2 diabetes.&lt;/p&gt;&lt;/div&gt;">insulin</a> levels. Additionally, Aloe vera supplementation led to improvements in lipid profiles, including decreased <a href="/outcomes/triglycerides/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Triglycerides&lt;/h6&gt;&lt;p&gt;Triglycerides refers to the fatty acids in your blood. They can be used for energy or stored into fat cells (i.e., body fat). Abnormal triglycerides raise the risk of cardiovascular disease (CVD).&lt;/p&gt;&lt;/div&gt;">triglycerides</a>, <a href="/outcomes/total-cholesterol/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Total cholesterol&lt;/h6&gt;&lt;p&gt;Total cholesterol refers to all the cholesterol in your blood (HDL-C and LDL-C). It is distinct from triglycerides.&lt;/p&gt;&lt;/div&gt;">total cholesterol</a> (TC), and low-density lipoprotein (<a href="/outcomes/ldl-c/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Low-density lipoprotein (LDL)&lt;/h6&gt;&lt;p&gt;LDL carries cholesterol from the liver to other parts of the body. Because higher levels of LDL cholesterol (LDL-C) tend to increase the risk of cardiovascular disease (CVD), LDL-C is often called the “bad cholesterol” (as opposed to HDL-C) — but the reality is more complex.&lt;/p&gt;&lt;/div&gt;">LDL</a>) levels, as well as an increase in high-density lipoprotein (<a href="/outcomes/hdl/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;High-density lipoprotein (HDL)&lt;/h6&gt;&lt;p&gt;&lt;em&gt;High-density lipoprotein&lt;/em&gt; (HDL) is a particle that carries cholesterol from your blood to your liver. Low levels of &lt;em&gt;HDL cholesterol&lt;/em&gt; (HDL-C) are associated with a higher risk of &lt;em&gt;cardiovascular disease&lt;/em&gt; (CVD), which is why HDL-C is often called the “good cholesterol” (as opposed to LDL-C) — but the reality is more complex.&lt;/p&gt;&lt;/div&gt;">HDL</a>) levels compared to a placebo.[reference|url=https://pubmed.ncbi.nlm.nih.gov/27347994|title=Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials|published=2016 Jun 23|authors=Yiyi Zhang, Wen Liu, Dan Liu, Tieyun Zhao, Haoming Tian|journal=Nutrients|] Similar results were observed in another meta-analysis.[reference|url=https://pubmed.ncbi.nlm.nih.gov/27152917|title=Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis.|published=2016-Jun|authors=Dick WR, Fletcher EA, Shah SA|journal=J Altern Complement Med|]

Aloe vera is commercially sold to treat burns and various skin conditions. While the evidence supporting its effectiveness is not robust, one <a href="/glossary/meta-analysis/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Meta-analysis&lt;/h6&gt;&lt;p&gt;A meta-analysis is usually produced as part of a systematic review. It combines the numerical results from several studies into an average number. Studies that differ too much in design cannot be properly meta-analyzed.&lt;/p&gt;&lt;/div&gt;">meta-analysis</a> suggested that burns treated with Aloe vera may heal more quickly than those given standard treatment.[reference|url=https://pubmed.ncbi.nlm.nih.gov/36264753|title=Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review.|published=2022-Nov-01|authors=Sharma S, Alfonso AR, Gordon AJ, Kwong J, Lin LJ, Chiu ES|journal=Adv Skin Wound Care|] Similarly, some studies indicate that Aloe vera may reduce the severity of <a href="/outcomes/psoriasis-symptoms/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Psoriasis Symptoms&lt;/h6&gt;&lt;p&gt;Psoriasis is a chronic skin disease that causes patches of thick, red, scaly skin on various parts of the body. Its cause is unknown and symptoms tend to wax and wane over time.&lt;/p&gt;&lt;/div&gt;">psoriasis symptoms</a> in individuals with mucocutaneous conditions.[reference|url=https://pubmed.ncbi.nlm.nih.gov/33336470|title=Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.|published=2021-Mar|authors=Gok Metin Z, Helvaci A, Gulbahar Eren M|journal=J Adv Nurs|] However, Aloe vera does not seem to be effective in improving symptoms of radiation dermatitis (RD), a common side effect of radiotherapy.[reference|url=https://pubmed.ncbi.nlm.nih.gov/36859690|title=Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.|published=2023-Mar-02|authors=Robijns J, Becherini C, Caini S, Wolf JR, van den Hurk C, Beveridge M, Lam H, Bonomo P, Chow E, Behroozian T|journal=Support Care Cancer|]
Topical application of Aloe vera may also be beneficial for nipple pain and irritation in <a href="/other/breastfeeding/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Breastfeeding&lt;/h6&gt;&lt;p&gt;Breastfeeding — also referred to as nursing — is the process of feeding breast milk to a child. This page refers to breastfeeding as an intervention (e.g., compared to infant formula) — please visit our lactation|lactation page to learn more about ways to improve breast milk production.&lt;/p&gt;&lt;/div&gt;">breastfeeding</a> women,[reference|url=https://pubmed.ncbi.nlm.nih.gov/36388847|title=The Effectiveness of Aloe Vera on Relief of Irritation and Nipple Pain in Lactating Women: Systematic Review and Meta-Analysis.|published=2022|authors=Maleki A, Youseflu S|journal=Obstet Gynecol Int|] although further research with stronger methodologies is needed to confirm these findings.
Additionally, Aloe vera may have benefits for oral health. Topical oral applications of Aloe vera in mouthwash or gels have been shown to reduce plaque formation, gum inflammation, and bleeding in people with periodontal disease (gum disease) to a greater degree than commonly used preparations (e.g., fluoride‑containing triclosan, chlorhexidine).[reference|url=https://pubmed.ncbi.nlm.nih.gov/34667378|title=Effect of Aloe vera as a local drug delivery agent in the management of periodontal diseases: A systematic review and meta-analysis|published=Sep-Oct 2021|authors=Ashwini Narendra Jadhav, Surekha Ramrao Rathod, Abhay Pandurang Kolte, Pranjali Vijaykumar Bawankar|journal=J Indian Soc Periodontol|] Furthermore, one meta-analysis found that, for the treatment of oral ulcers, various topical preparations of Aloe vera gel had better therapeutic effect and shorter therapy duration than a <a href="/glossary/control/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Control&lt;/h6&gt;&lt;p&gt;A control provides a comparator that allows determination of the safety and effectiveness of a treatment. For example, a control group is a group of study participants that does not receive the experimental treatment. Instead, participants in the control group may receive a standard treatment, a glossary:placebo, or nothing, while keeping all other aspects of the study the same for the control group as for the group receiving the experimental treatment.&lt;/p&gt;&lt;/div&gt;">control</a>, although their effects on ulcer size and subjective pain did not differ significantly from the control.[reference|url=https://pubmed.ncbi.nlm.nih.gov/36504087|title=Effects of Aloe Vera in the Treatment of Oral Ulcers: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.|published=2022-Dec-12|authors=Zou H, Liu Z, Wang Z, Fang J|journal=Oral Health Prev Dent|]
Finally, some Aloe vera preparations can also be taken orally, and one meta-analysis found that Aloe vera may be effective in improving symptoms of <a href="/conditions/irritable-bowel-syndrome/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Irritable Bowel Syndrome&lt;/h6&gt;&lt;p&gt;&lt;em&gt;Irritable Bowel Syndrome&lt;/em&gt; (IBS) is a common functional disorder of the large intestine characterized by long-term changes in bowel habits (e.g., frequent diarrhea or constipation) and abdominal pain. The exact causes are unknown, but research suggests that multiple factors — such as the gut-brain axis, abnormal muscular contractions, and gut microbes — could play a role in the disease. IBS can be managed with dietary modifications, psychotherapy, supplements, and prescription medications.&lt;/p&gt;&lt;/div&gt;">irritable bowel syndrome</a> (IBS), although the evidence is not strong.[reference|url=https://pubmed.ncbi.nlm.nih.gov/30153721|title=Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.|published=2018-Oct-01|authors=Hong SW, Chun J, Park S, Lee HJ, Im JP, Kim JS|journal=J Neurogastroenterol Motil|]

Consumption of Aloe vera latex is not recommended during pregnancy. This is mainly due to its anthraquinone component, which, in addition to its laxative properties, may stimulate uterine contractions, potentially leading to premature labor or miscarriage.[reference|url=https://pubmed.ncbi.nlm.nih.gov/17613130|title=Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.|published=2007|authors=Cosmetic Ingredient Review Expert Panel|journal=Int J Toxicol|][reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|] One case study reported adverse effects in a fetus when the mother consumed Aloe vera, including intestinal peristalsis, the release of meconium in the uterus, and kidney damage.[reference|url=https://pubmed.ncbi.nlm.nih.gov/17613130|title=Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.|published=2007|authors=Cosmetic Ingredient Review Expert Panel|journal=Int J Toxicol|]
Additionally, the anthraquinone component of Aloe vera latex and juice may be excreted into breast milk, potentially causing diarrhea in nursing infants. [reference|url=https://pubmed.ncbi.nlm.nih.gov/17613130|title=Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.|published=2007|authors=Cosmetic Ingredient Review Expert Panel|journal=Int J Toxicol|]

Aloe vera topical gel is generally well-tolerated, but there have been reports of hypersensitive skin reactions.[reference|url=https://pubmed.ncbi.nlm.nih.gov/33336470|title=Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.|published=2021-Mar|authors=Gok Metin Z, Helvaci A, Gulbahar Eren M|journal=J Adv Nurs|] 
Additionally, Aloe vera latex, a yellow-brownish liquid extracted from the skin of the plant's leaves and traditionally used as a laxative, and Aloe vera whole leaf extract, which contains the latex, may pose a risk of toxicity due to the latex’s high content of anthranoids.[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|][reference|url=https://pubmed.ncbi.nlm.nih.gov/27009750|title=Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis|published=2016 Apr|authors=N Suksomboon, N Poolsup, S Punthanitisarn|journal=J Clin Pharm Ther|]
Topical and oral use of Aloe vera can also theoretically cause skin irritation, <a href="/conditions/urticaria/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Urticaria&lt;/h6&gt;&lt;p&gt;Urticaria — also known as hives, nettle rash, or wheals — can be an acute or chronic condition. Acute urticaria typically results from exposure to an allergen or infection and lasts less than 6 weeks, whereas chronic urticaria lasts longer and seems to be related to autoimmune dysfunction.&lt;/p&gt;&lt;/div&gt;">urticaria</a>, cramping, and <a href="/outcomes/diarrhea-symptoms/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Diarrhea Symptoms&lt;/h6&gt;&lt;p&gt;Diarrhea refers to loose, watery stools that may be caused by a virus, contaminated food, or disorders such as inflammatory bowel disease.&lt;/p&gt;&lt;/div&gt;">diarrhea</a> in people who are allergic to other plants in the same family (e.g., onion).[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]
Regarding interactions with medications, there is evidence of a potential herb-drug interaction between Aloe vera whole leaf extract and sevoflurane, a general anesthetic.[reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]
Finally, Aloe vera has been associated with cases of acute hepatitis (liver inflammation). This side effect typically occurs within an oral dosage range of 250–500 mg per day, and while the effects appear reversible, the exact mechanism of toxicity is not fully understood.[reference|url=https://pubmed.ncbi.nlm.nih.gov/17726067|title=Oral aloe vera-induced hepatitis.|published=2007-Oct|authors=Bottenberg MM, Wall GC, Harvey RL, Habib S|journal=Ann Pharmacother|][reference|url=https://pubmed.ncbi.nlm.nih.gov/20191055|title=Aloe-induced toxic hepatitis.|published=2010-Mar|authors=Yang HN, Kim DJ, Kim YM, Kim BH, Sohn KM, Choi MJ, Choi YH|journal=J Korean Med Sci|][reference|url=https://pubmed.ncbi.nlm.nih.gov/26986231|title=Aloe vera: A review of toxicity and adverse clinical effects.|published=2016-Apr-02|authors=Guo X, Mei N|journal=J Environ Sci Health C Environ Carcinog Ecotoxicol Rev|]

Aloe vera contains more than 75 bioactive compounds, including vitamins, enzymes, minerals, anthraquinones, sugars, hormones, and fatty acids, among others.[reference|url=https://pubmed.ncbi.nlm.nih.gov/32183224|title=Pharmacological Update Properties of and its Major Active Constituents.|published=2020-Mar-13|authors=Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP|journal=Molecules|] Therefore, several mechanisms of action have been proposed for the effects of Aloe vera.
<a href="/glossary/in-vitro-study/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;In Vitro Study&lt;/h6&gt;&lt;p&gt;&lt;em&gt;In vitro&lt;/em&gt; (Latin for “within the glass”) refers to studies that are performed outside of a living organism. In scientific research, this often involves performing experiments on bacterial, animal, or human cells growing in lab culture dishes.&lt;/p&gt;&lt;/div&gt;">In vitro</a> studies suggest that aloesin, aloin, and emodin are the main compounds responsible for the skin-protective properties of Aloe vera, thanks to their antioxidant and anti-inflammatory mechanisms.[reference|url=https://pubmed.ncbi.nlm.nih.gov/32183224|title=Pharmacological Update Properties of and its Major Active Constituents.|published=2020-Mar-13|authors=Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP|journal=Molecules|] Magnesium lactate present in Aloe vera may also contribute to alleviating skin <a href="/outcomes/itching/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Itching&lt;/h6&gt;&lt;p&gt;Itching, also known as pruritis, is an uncomfortable physical sensation that drives an urge to scratch the itchy area. It is multifactorial; causes include skin conditions, insects, liver disease, medications, pregnancy, nerve damage, cancer, and more.&lt;/p&gt;&lt;/div&gt;">itching</a> and irritation by reducing histamine production.[reference|url=https://pubmed.ncbi.nlm.nih.gov/23194624|title=The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice.|published=1996-Jan|authors=Bunyapraphatsara N, Jirakulchaiwong S, Thirawarapan S, Manonukul J|journal=Phytomedicine|] Additionally, the glycoprotein fraction of Aloe vera appears to inhibit thromboxanes and promote type-III <a href="/supplements/type-ii-collagen/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;Type-II Collagen&lt;/h6&gt;&lt;p&gt;Type II collagen (CII) is a protein and component of joint cartilage. Oral ingestion of CII in its undenatured form may reduce autoimmunity to the body's own CII, resulting in less joint inflammation in instances of osteoarthritis and rheumatism.&lt;/p&gt;&lt;/div&gt;">collagen</a> production, which facilitates skin healing.[reference|url=https://pubmed.ncbi.nlm.nih.gov/36337821|title=A Systematic Review and Meta-Analysis Comparing Burn Healing Outcomes Between Silver Sulfadiazine and Aloe vera.|published=2022-Oct|authors=Levin NJ, Erben Y, Li Y, Brigham TJ, Bruce AJ|journal=Cureus|]
Another essential constituent of Aloe vera, acemannan, is a mucopolysaccharide that exhibits anti-inflammatory and gastroprotective properties.[reference|url=https://pubmed.ncbi.nlm.nih.gov/32183224|title=Pharmacological Update Properties of and its Major Active Constituents.|published=2020-Mar-13|authors=Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP|journal=Molecules|] Furthermore, anthraquinones found in Aloe vera latex confer its laxative effect by increasing intestinal water content, stimulating mucus secretion, and enhancing intestinal peristalsis.[reference|url=https://pubmed.ncbi.nlm.nih.gov/19882025|title=Aloe vera: a short review.|published=2008|authors=Surjushe A, Vasani R, Saple DG|journal=Indian J Dermatol|][reference|url=https://pubmed.ncbi.nlm.nih.gov/30153721|title=Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.|published=2018-Oct-01|authors=Hong SW, Chun J, Park S, Lee HJ, Im JP, Kim JS|journal=J Neurogastroenterol Motil|]
Regarding its hypoglycemic effect, Aloe vera may work by reducing glucose absorption in the gastrointestinal tract after food, stimulating glucose catabolism, and suppressing gluconeogenesis (glucose production). Activation of <a href="/glossary/ampk/" class="popover" data-tooltip="&lt;div&gt;&lt;h6&gt;AMPK&lt;/h6&gt;&lt;p&gt;&lt;em&gt;Adenosine monophosphate-activated protein kinase&lt;/em&gt; (AMPK) is an enzyme that helps regulate energy in the body.&lt;/p&gt;&lt;/div&gt;">AMPK</a>, akin to the mechanism of action of metformin (a medication for type 2 diabetes), is also proposed as a possible pathway for the hypoglycemic effects of Aloe vera.[reference|url=https://pubmed.ncbi.nlm.nih.gov/27009750|title=Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis|published=2016 Apr|authors=N Suksomboon, N Poolsup, S Punthanitisarn|journal=J Clin Pharm Ther|]

Aloe Vera

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