Baikal skullcap is most often used for Brain Health. The Examine Database covers Depression.

Baikal skullcap

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•Last Updated: August 28, 2025

Scutellaria baicalensis (Chinese Skullcap) is a traditional chinese medicine for the purposes of cardiovascular and cognitive health as well as longevity. It appears to be a good source for flavonoid compounds, and some components are quite potent.

177 participants in 1 trial

Examine Evidence Grades

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Last Updated:August 28, 2025

177 participants in 1 trial

Examine Evidence Grades

Dosage information

Although there is a lack of human evidence to support the optimal dosage of scutellaria baicalensis for supplementation purposes, the doses that appear optimal in rat and mouse models suggest that an oral dose of around 500mg of the root extract should be efficacious.

Examine Database: Baikal skullcap

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4 outcomes

1 Study

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Skullcap, saffron, or both for depression symptoms?

In this 6-week randomized controlled trial in 177 adults with mild to moderate depression, supplementing with Baikal skullcap, saffron, or both did not reduce depression symptoms compared to a placebo.

Research Breakdown

Examine Database References

Depression Symptoms - Dormal V, Suchareau M, Copine S, Simar L, Deldicque LThe Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study.Nutrients.(2025 Feb 26)