Can black cohosh be taken with St. John’s wort?

Q: Can black cohosh be taken with St. John’s wort?

The combination of St. John’s wort ( Hypericum perforatum ) and high doses of iCR appears to be more effective at improving psychological climacteric symptoms, like depression, than black cohosh alone. Furthermore, the frequency of adverse events did not significantly differ between iCR taken alone or vs. iCR in combination with St. John’s wort.<a href="#ref-1" id="ref-link-1" class="ref-link popover" data-tooltip='<div><p class="mb-3">Castelo-Branco C, et al. <a href="https://pubmed.ncbi.nlm.nih.gov/33021111" target="\_blank" rel="noopener noreferrer">Review &amp; meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence.</a></p>Climacteric (2021-Apr)</div>'> [1]

Question

Accepted Answer

The combination of St. John’s wort (Hypericum perforatum) and high doses of iCR appears to be more effective at improving psychological climacteric symptoms, like depression, than black cohosh alone. Furthermore, the frequency of adverse events did not significantly differ between iCR taken alone or vs. iCR in combination with St. John’s wort.^[1]

Can black cohosh be taken with St. John’s wort?

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