During menopause, the drop in estrogen levels results in gradual bone loss.
Supplementation with black cohosh in ovariectomized rats resulted in a reduction of bone loss from 53.7% to 38.7% over time.[1] Positive effects on bone metabolism were also observed in humans when measuring urinary markers and alkaline phosphatase. However, the only human trial to measure bone mineral density did not show any effects from black cohosh intervention.[2]
References
- ^Seidlova-Wuttke D, Hesse O, Jarry H, Christoffel V, Spengler B, Becker T, Wuttke WEvidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta.Eur J Endocrinol.(2003-Oct)
- ^Michael Bebenek, Wolfgang Kemmler, Simon von Stengel, Klaus Engelke, Willi A KalenderEffect of exercise and Cimicifuga racemosa (CR BNO 1055) on bone mineral density, 10-year coronary heart disease risk, and menopausal complaints: the randomized controlled Training and Cimicifuga racemosa Erlangen (TRACE) studyMenopause.(2010 Jul)