How does BPC-157 work?

    Last Updated: November 15, 2023

    BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[1][2][3]

    BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[4]

    References

    1. ^Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Stambolija V, Zoricic Z, Vrcic H, Sebecic BFocus on ulcerative colitis: stable gastric pentadecapeptide BPC 157Curr Med Chem.(2012)
    2. ^Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHThe promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationJ Appl Physiol (1985).(2011 Mar)
    3. ^Japjec M, Horvat Pavlov K, Petrovic A, Staresinic M, Sebecic B, Buljan M, Vranes H, Giljanovic A, Drmic D, Japjec M, Prtoric A, Lovric E, Batelja Vuletic L, Dobric I, Boban Blagaic A, Skrtic A, Seiwerth S, Predrag SStable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disable Myotendinous Junctions in Rats.Biomedicines.(2021-Oct-27)
    4. ^Sven Seiwerth, Marija Milavic, Jaksa Vukojevic, Slaven Gojkovic, Ivan Krezic, Lovorka Batelja Vuletic, Katarina Horvat Pavlov, Andrea Petrovic, Suncana Sikiric, Hrvoje Vranes, Andreja Prtoric, Helena Zizek, Tajana Durasin, Ivan Dobric, Mario Staresinic, Sanja Strbe, Mario Knezevic, Marija Sola, Antonio Kokot, Marko Sever, Eva Lovric, Anita Skrtic, Alenka Boban Blagaic, Predrag SikiricStable Gastric Pentadecapeptide BPC 157 and Wound HealingFront Pharmacol.(2021 Jun 29)