How does CBD work?

    Researchedby:
    Pierre-Alexandre Sicart
    Last Updated: October 25, 2023

    CBD works in myriad ways, which are still being explored. For instance, it may reduce pain and stress via the TRPV1 receptor,[1][2][3] stress and depression via the 5HTI-alpha receptor,[4][5] and inflammation via the A2A receptors.[6]

    Unfortunately, CBD seems to work better in combination with THC.

    References

    1. ^Ho KW, Ward NJ, Calkins DJTRPV1: a stress response protein in the central nervous systemAm J Neurodegener Dis.(2012)
    2. ^Jara-Oseguera A, Simon SA, Rosenbaum TTRPV1: on the road to pain reliefCurr Mol Pharmacol.(2008 Nov)
    3. ^Terzian AL, Aguiar DC, Guimarães FS, Moreira FAModulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal grayEur Neuropsychopharmacol.(2009 Mar)
    4. ^Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A, Adell A, Díaz ÁCannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptorsNeuropharmacology.(2016 Apr)
    5. ^Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in ratsBr J Pharmacol.(2009 Jan)
    6. ^Mecha M, Feliú A, Iñigo PM, Mestre L, Carrillo-Salinas FJ, Guaza CCannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptorsNeurobiol Dis.(2013 Nov)