In humans, a 15-gram dose of citrulline taken acutely (in the short term) does not appear to cause diarrhea or intestinal upset.[1] In this respect, citrulline is notably different from both ornithine and arginine, which may cause diarrhea at 10-gram doses when taken in boluses[2][3] due to limited absorption of these amino acids, which then proceed to the colon to cause osmotic diarrhea.[2]
References
- ^C Moinard, I Nicolis, N Neveux, S Darquy, S Bénazeth, L CynoberDose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic studyBr J Nutr.(2008 Apr)
- ^Grimble GKAdverse gastrointestinal effects of arginine and related amino acids.J Nutr.(2007-Jun)
- ^Collier SR, Casey DP, Kanaley JAGrowth hormone responses to varying doses of oral arginineGrowth Horm IGF Res.(2005 Apr)