What are citrulline’s main drawbacks?

    Researchedby:
    Louie Neri

    Fact-checked

    by:

    Peter Woznik
    Last Updated: October 25, 2023

    Although the safety of long-term supplementation with high doses of citrulline warrants further investigation, research to date suggests that it is well tolerated in most individuals. Unlike arginine and ornithine, high doses of citrulline don't seem to result in gastrointestinal distress.[1]