Long-term usage of statins (cholesterol-lowering drugs) has been associated with lower CoQ10 levels.[1] However, it remains unclear whether supplementation with CoQ10 would be beneficial when prescribed alongside statin therapy.[2]
It has been observed that supplementation with 100 mg of CoQ10 in individuals treated with atorvastatin (a statin) may reverse some cardiovascular complications and address the CoQ10 deficiency induced by statins, with one study noting that a 42% reduction in CoQ10 was reversed to a 127% increase relative to baseline.[3] Nevertheless, one meta-analysis found that supplementation with CoQ10 did not result in significant changes in muscle pain or creatine kinase (CK) activity
References
- ^Hargreaves I, Heaton RA, Mantle DDisorders of Human Coenzyme Q10 Metabolism: An Overview.Int J Mol Sci.(2020-Sep-13)
- ^Littarru GP, Langsjoen PCoenzyme Q10 and statins: biochemical and clinical implications.Mitochondrion.(2007-Jun)
- ^Mabuchi H, Nohara A, Kobayashi J, Kawashiri MA, Katsuda S, Inazu A, Koizumi J,Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study.Atherosclerosis.(2007-Dec)