What is ephedrine?

    Last Updated: October 25, 2023

    Ephedrine is a stimulant that activates the sympathetic nervous system. It is chemically synthesized for use as a drug in clinical practice, but ephedrine is also one of the ephedrine-type alkaloids that are extracted from plants in the Ephedra genus and have effects on the heart, vascular system, and other organs.[1] Supplements derived from Ephedra plants (e.g., the Chinese botanical Ma Huang) are often referred to as “ephedra” and are marketed for many uses, including weight loss.[2] Due to ephedra’s serious side effects, the Food and Drug Administration (FDA) has banned the sale of dietary supplements containing ephedra and ephedrine-type alkaloids in the United States.[3]

    References

    1. ^González-Juárez DE, Escobedo-Moratilla A, Flores J, Hidalgo-Figueroa S, Martínez-Tagüeña N, Morales-Jiménez J, Muñiz-Ramírez A, Pastor-Palacios G, Pérez-Miranda S, Ramírez-Hernández A, Trujillo J, Bautista EA Review of the genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties.Molecules.(2020-Jul-20)
    2. ^Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagné JEfficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysisJAMA.(2003 Mar 26)
    3. ^Food and Drug Administration, HHSFinal rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk. Final ruleFed Regist.(2004 Feb 11)