Fish oil reduces triglyceride levels by decreasing triglyceride-rich lipoprotein synthesis and release by the liver. It may also increase clearance of triglycerides by upregulating the lipoprotein lipase enzyme.[1] EPA and DHA from fish oil are usually initially incorporated into the phospholipid layer of cell membranes in platelets, neutrophils, and red blood cells. EPA especially seems to stabilize cell membranes and inhibit lipid oxidation, which can help regulate vascular tone, improve cell signaling, and reduce inflammation.[2]
How does fish oil work?
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•Last Updated: May 16, 2025
Fish oil works by lowering triglyceride levels through reduced synthesis and release by the liver and enhanced clearance via lipoprotein lipase. Additionally, EPA and DHA from fish oil are incorporated into cell membranes, where they stabilize membranes, inhibit lipid oxidation, and help regulate vascular tone and inflammation.