Fish oil reduces triglyceride levels by decreasing triglyceride-rich lipoprotein synthesis and release by the liver. It may also increase clearance of triglycerides by upregulating the lipoprotein lipase enzyme.[1] EPA and DHA from fish oil are usually initially incorporated into the phospholipid layer of cell membranes in platelets, neutrophils, and red blood cells. EPA especially seems to stabilize cell membranes and inhibit lipid oxidation, which can help regulate vascular tone, improve cell signaling, and reduce inflammation.[2]
