Folic acid supplementation may have minor benefits on blood glucose regulation, but these effects are probably not clinically relevant. Research suggests that folic acid may slightly reduce fasting blood glucose, fasting insulin, and HOMA-IR (a marker of insulin resistance), but not in people with type 2 diabetes. Additionally, folic acid does not appear to affect hemoglobin A1c.[1][2][3]
References
- ^Asbaghi O, Ashtary-Larky D, Bagheri R, Moosavian SP, Olyaei HP, Nazarian B, Rezaei Kelishadi M, Wong A, Candow DG, Dutheil F, Suzuki K, Alavi Naeini AFolic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.Nutrients.(2021-Jul-09)
- ^Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong WEffect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis.Diabetes Res Clin Pract.(2012-Oct)
- ^Zhao JV, Schooling CM, Zhao JXThe effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Ann Epidemiol.(2018-Apr)