Overview

What is glucosamine?

What are glucosamine’s main benefits?

What are glucosamine’s main drawbacks?

How does glucosamine work?

Dosage information

Glucosamine sulfate is typically taken as a 500 mg dose three times a day with food.^[1]

The benefits of glucosamine are dose-dependent, and some studies on athletes used up to 2,000–3,000 mg a day, taken in divided doses.^[2]

Glucosamine sulfate salts are usually taken as a one-a-day dose of 1500 mg glucosamine.^[3]

Examine Database: Glucosamine

Show Conditions

Health Condition/Goal	Health Outcome	Evidence
Osteoarthritis	3 Outcomes	22 Studies
Kashin-Beck Disease	1 Outcome	2 Studies
Bone Health	1 Outcome	1 Study
Acute Nonspecific Knee Pain	2 Outcomes	1 Study

Osteoarthritis

3 Outcomes

22 Studies

Kashin-Beck Disease

1 Outcome

2 Studies

Bone Health

1 Outcome

1 Study

Acute Nonspecific Knee Pain

2 Outcomes

1 Study

Osteoarthritis

Kashin-Beck Disease

Bone Health

Acute Nonspecific Knee Pain

Research FeedRead all studies

The benefits of a multi-ingredient supplement in women with recurrent urinary tract infection

In this randomized crossover trial in sexually active women with recurrent urinary tract infection, taking a supplement containing hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improved sexual symptoms and urinary symptoms.

Examining the efficacy of two multi-ingredient supplements for the treatment of knee osteoarthritis

The role of glucosamine and chondroitin in knee osteoarthritis

Glucosamine sulfate for knee osteoarthritis

Can glucosamine help with osteoarthritis of the jaw?

Frequently asked questions

What is the difference between the various forms of glucosamine?

What are the other benefits of glucosamine?

Can glucosamine be taken alongside other supplements?

How does glucosamine compare to other treatments?

Is glucosamine suitable for people with a shellfish allergy?

Update History

Standard FAQ and database update
major

Research written by

Giulia Guerrini

Edited by

Natalka Roshak

Reviewed by

Nick Milazzo

Small tweak to reference #5
minor

Research written by

Giulia Guerrini

Edited by

Natalka Roshak

Reviewed by

Nick Milazzo

References

Examine Database References

Osteoarthritis Symptoms - Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells GGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2005 Apr 18)
Osteoarthritis Symptoms - Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan BAyurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trialRheumatology (Oxford).(2013 Jan 30)
Osteoarthritis Symptoms - Vlad SC, LaValley MP, McAlindon TE, Felson DTGlucosamine for pain in osteoarthritis: why do trial results differArthritis Rheum.(2007 Jul)
Osteoarthritis Symptoms - Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JYStructural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysisArch Intern Med.(2003 Jul 14)
Osteoarthritis Symptoms - Yongsak Wangroongsub, Aree Tanavalee, Vajara Wilairatana, Srihatach NgarmukosComparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind studyJ Med Assoc Thai.(2010 Jul)
Osteoarthritis Symptoms - Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJGlucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisN Engl J Med.(2006 Feb 23)
Osteoarthritis Symptoms - Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, Reichenbach S, Trelle SEffects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysisBMJ.(2010 Sep 16)
Osteoarthritis Symptoms - Houpt JB, McMillan R, Wein C, Paget-Dellio SDEffect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the kneeJ Rheumatol.(1999 Nov)
Osteoarthritis Symptoms - Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MCGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2001)
Osteoarthritis Symptoms - McAlindon TE, LaValley MP, Gulin JP, Felson DTGlucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysisJAMA.(2000 Mar 15)
Osteoarthritis Symptoms - Pujalte JM, Llavore EP, Ylescupidez FRDouble-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosisCurr Med Res Opin.(1980)
Osteoarthritis Symptoms - McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara KEffectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trialAm J Med.(2004 Nov 1)
Osteoarthritis Symptoms - Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett CLong-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialLancet.(2001 Jan 27)
Osteoarthritis Symptoms - Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco JGlucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparatorArthritis Rheum.(2007 Feb)
Osteoarthritis Symptoms - Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LCGlucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind studyArch Intern Med.(2002 Oct 14)
Osteoarthritis Symptoms - Hughes R, Carr AA randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the kneeRheumatology (Oxford).(2002 Mar)
Osteoarthritis Symptoms - Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola GRandomized, controlled trial of glucosamine for treating osteoarthritis of the kneeWest J Med.(2000 Feb)
Pain - Noack W, Fischer M, Förster KK, Rovati LC, Setnikar IGlucosamine sulfate in osteoarthritis of the kneeOsteoarthritis Cartilage.(1994 Mar)
Temporomandibular Disorder (TMD) Symptoms - Thie NM, Prasad NG, Major PWEvaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trialJ Rheumatol.(2001 Jun)
Temporomandibular Disorder (TMD) Symptoms - Cahlin BJ, Dahlström LNo effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term studyOral Surg Oral Med Oral Pathol Oral Radiol Endod.(2011 Dec)
Temporomandibular Disorder (TMD) Symptoms - Haghighat A, Behnia A, Kaviani N, Khorami BEvaluation of Glucosamine sulfate and Ibuprofen effects in patients with temporomandibular joint osteoarthritis symptom.J Res Pharm Pract.(2013 Jan)
Temporomandibular Disorder (TMD) Symptoms - Cen X, Liu Y, Wang S, Yang X, Shi Z, Liang XGlucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.Oral Dis.(2018 Apr)
Kashin-Beck Disease Symptoms - Liu W, Liu G, Pei F, Liu Y, Zhou Z, Li J, Shen B, Kang P, Xie Q, Ma XKashin-Beck disease in Sichuan, China: report of a pilot open therapeutic trialJ Clin Rheumatol.(2012 Jan)
Kashin-Beck Disease Symptoms - Yue J, Yang M, Yi S, Dong B, Li W, Yang Z, Lu J, Zhang R, Yong JChondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled studyOsteoarthritis Cartilage.(2012 Jul)
Range of Motion - Ostojic SM, Arsic M, Prodanovic S, Vukovic J, Zlatanovic MGlucosamine administration in athletes: effects on recovery of acute knee injuryRes Sports Med.(2007 Apr-Jun)
CTX-II - Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka IEvaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer playersInt J Mol Med.(2009 Oct)

Glucosamine

Overview

What is glucosamine?

What are glucosamine’s main benefits?

What are glucosamine’s main drawbacks?

How does glucosamine work?

Dosage informationMedical disclaimer

Examine Database: Glucosamine

Research FeedRead all studies

Frequently asked questions

What is the difference between the various forms of glucosamine?

What are the other benefits of glucosamine?

Can glucosamine be taken alongside other supplements?

How does glucosamine compare to other treatments?

Is glucosamine suitable for people with a shellfish allergy?

Update History

Standard FAQ and database updatemajor

Small tweak to reference #5minor

References

Examine Database References

Examine Database References

Examine Database: Glucosamine

Research FeedRead all studies

Dosage information

Standard FAQ and database update
major

Small tweak to reference #5
minor