Dosage Information

Formulation

Glycine is most often taken as a powder dissolved in liquid (water, juice, etc.) or in a capsule.

Range of dosages studied

Dosages of glycine used in studies have generally ranged from 3 grams to 60 grams daily, for durations of up to 4 months. Dosages above 30 grams daily have only been used in the context of schizophrenia.^[1]

Examine Database: Glycine

Health Condition/Goal	Health Outcome	Grade	Evidence	Effect
Schizophrenia	2 outcomes		2 Studies
Sleep Health	3 outcomes		3 Studies

2 outcomes

3 outcomes

Research FeedRead all studies

Glycine for severe COVID-19

In this randomized controlled trial in participants hospitalized with severe COVID-19, enteral glycine supplementation did not reduce the risk of death or shorten the duration of mechanical ventilation.

The role of molecular weight and hydroxyproline in collagen supplements

Collagen supplementation for sleep among physically active men

Could supplementing with glycine and N-acetylcysteine improve “hallmarks of aging”?

Glycine and NAC reduce markers of premature aging in HIV patients

Frequently Asked Questions

Does glycine affect blood sugar control?

Does glycine affect joint health?

What are other names for Glycine?

Update History

FAQ and Examine Database update
major

Research written by

Katie Jantz

Edited by

Conni Covington

Reviewed by

Giulia Guerrini

Research Breakdown

References

Examine Database References

Sleep Quality - Kentaro Inagawa, Takenori Hiraoka, Tohru Kohda, Wataru Yamadera, Michio TakahashiSubjective effects of glycine ingestion before bedtime on sleep qualitySleep and Biological Rhythms.()
Sleep Quality - Wataru Yamadera, Kentaro Inagawa, Shintaro Chiba, Makoto Bannai, Michio Takahashi, Kazuhiko NakayamaGlycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changesSleep and Biological Rhythms.()
Sleep Quality - Bannai M, Kawai N, Ono K, Nakahara K, Murakami NThe effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteersFront Neurol.(2012 Apr 18)
Schizophrenia symptoms - Mishra A, Maiti R, Mishra BR, Srinivasan AEfficacy of pharmacological agents for the management of treatment-resistant schizophrenia: a network meta-analysis.Expert Rev Clin Pharmacol.(2024 Mar)
Schizophrenia symptoms - Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DCHigh-dose glycine added to olanzapine and risperidone for the treatment of schizophreniaBiol Psychiatry.(2004 Jan 15)
Schizophrenia symptoms - Tuominen HJ, Tiihonen J, Wahlbeck KGlutamatergic drugs for schizophrenia.Cochrane Database Syst Rev.(2006 Apr 19)

Glycine

Overview

What is glycine?

What are glycine’s main benefits?

What are glycine’s main drawbacks?

How does glycine work?

Dosage Information

Formulation

Range of dosages studied

Examine Database: Glycine

Research FeedRead all studies

Frequently Asked Questions

Does glycine affect blood sugar control?

Does glycine affect joint health?

What are other names for Glycine?

Update History

FAQ and Examine Database update
major

Research Breakdown

References

Examine Database References

Examine Database References

Examine Database: Glycine

Research FeedRead all studies

Glycine

Overview

What is glycine?

What are glycine’s main benefits?

What are glycine’s main drawbacks?

How does glycine work?

Dosage InformationMedical disclaimer

Formulation

Range of dosages studied

Examine Database: Glycine

Research FeedRead all studies

Frequently Asked Questions

Does glycine affect blood sugar control?

Does glycine affect joint health?

What are other names for Glycine?

Update History

FAQ and Examine Database updatemajor

Research Breakdown

References

Examine Database References

Examine Database References

Examine Database: Glycine

Research FeedRead all studies

Dosage Information

FAQ and Examine Database update
major