What are the other forms of hesperidin?

    Last Updated: October 13, 2024

    Glucosyl-hesperidin (G-Hesperidin) is a synthetically modified form of hesperidin with three (instead of two) glycoside groups. This modification greatly enhances its water solubility and bioavailability compared to regular hesperidin.[1] Once ingested, G-hesperidin is converted to hesperidin, which is then converted into hesperetin in the colon.

    Another synthetic variant of hesperidin is hesperidin-7,3'-O-dimethylether (HDME). This variant is more lipid-soluble and has higher phosphodiesterase inhibitory potential than hesperetin.[2]

    References

    1. ^Gonçalves TT, Lazaro CM, De Mateo FG, Campos MC, Mezencio JG, Claudino MA, de O Carvalho P, Webb RC, Priviero FBEffects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet.Diabetes Metab Syndr Obes.(2018)
    2. ^Yang YL, Hsu HT, Wang KH, Han CY, Chen CM, Chen CM, Ko WCHesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.J Biomed Sci.(2011-Nov-11)