Hyaluronic Acid

    Written by:
    Megan Michaux

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    Nick Milazzo
    Last Updated: September 5, 2023

    Hyaluronic acid (HA) is a large polysaccharide that is found naturally throughout the body and in high concentrations in the skin, the joint fluid, and the eye. It plays a role in many important bodily functions, including wound healing, joint lubrication and ovulation. As a supplement, it is most frequently used for joint health, to treat dry eyes, and in anti-aging products for the skin.

    Overview

    Dosage information

    For oral supplementation, the recommended dosage is 120 mg per day, with supplements usually available in either 60 mg or 120 mg tablets.[1]

    For dry eye treatments, drops are usually available in 0.3% solutions, although they may be effective from as low as 0.1%.[2]

    Topical creams and serums range from 0.1% to 0.3% HA concentrations, and will contain a mixture of high- and low-molecular-weight HA.[3]

    Examine Database: Hyaluronic Acid

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    Examine Database References

    1. Dermatitis Severity - Tai RZ, Loh EW, Tsai JT, Tam KWEffect of hyaluronic acid on radiotherapy-induced mucocutaneous side effects: a meta-analysis of randomized controlled trials.Support Care Cancer.(2022-Jun)
    2. Dry Eye Symptoms - Yun-Jung Yang, Won-Young Lee, Young-Jin Kim, Yeon-Pyo HongA Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye SyndromeInt J Environ Res Public Health.(2021 Mar 1)