Myo-inositol is sometimes given intravenously for the nutritional management of premature babies. While this is likely safe for the baby,[1][2][3] the current evidence shows that myo-inositol is unlikely to reduce mortality (risk of death) or prevent conditions like retinopathy of prematurity and respiratory distress syndrome when given intravenously to premature babies.[4][3][5]
References
- ^Phelps DL, Ward RM, Williams RL, Watterberg KL, Laptook AR, Wrage LA, Nolen TL, Fennell TR, Ehrenkranz RA, Poindexter BB, Michael Cotten C, Hallman MK, Frantz ID, Faix RG, Zaterka-Baxter KM, Das A, Bethany Ball M, Michael O'Shea T, Backstrom Lacy C, Walsh MC, Shankaran S, Sánchez PJ, Bell EF, Higgins RDPharmacokinetics and safety of a single intravenous dose of myo-inositol in preterm infants of 23-29 wk.Pediatr Res.(2013-Dec)
- ^Phelps DL, Ward RM, Williams RL, Nolen TL, Watterberg KL, Oh W, Goedecke M, Ehrenkranz RA, Fennell T, Poindexter BB, Cotten CM, Hallman M, Frantz ID, Faix RG, Zaterka-Baxter KM, Das A, Ball MB, Lacy CB, Walsh MC, Carlo WA, Sánchez PJ, Bell EF, Shankaran S, Carlton DP, Chess PR, Higgins RDSafety and pharmacokinetics of multiple dose myo-inositol in preterm infants.Pediatr Res.(2016-Aug)
- ^Du Y, He Y, Wang YL, Zhou JG, Chen CThe efficacy and safety of inositol supplementation in preterm infants to prevent retinopathy of prematurity: a systematic review and meta-analysis.BMC Ophthalmol.(2019-Jun-25)
- ^Alexandra Howlett, Arne Ohlsson, Nishad PlakkalInositol in preterm infants at risk for or having respiratory distress syndromeCochrane Database Syst Rev.(2019 Jul 8)
- ^Phelps DL, Watterberg KL, Nolen TL, Cole CA, Cotten CM, Oh W, Poindexter BB, Zaterka-Baxter KM, Das A, Lacy CB, Scorsone AM, Walsh MC, Bell EF, Kennedy KA, Schibler K, Sokol GM, Laughon MM, Lakshminrusimha S, Truog WE, Garg M, Carlo WA, Laptook AR, Van Meurs KP, Carlton DP, Graf A, DeMauro SB, Brion LP, Shankaran S, Orge FH, Olson RJ, Mintz-Hittner H, Yang MB, Haider KM, Wallace DK, Chung M, Hug D, Tsui I, Cogen MS, Donahue JP, Gaynon M, Hutchinson AK, Bremer DL, Quinn G, He YG, Lucas WR, Winter TW, Kicklighter SD, Kumar K, Chess PR, Colaizy TT, Hibbs AM, Ambalavanan N, Harmon HM, McGowan EC, Higgins RD,Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm InfantsJAMA.(2018-Oct-23)