Isoleucine is an amino acid used by the body during protein synthesis, which is required for muscle growth and recovery. In terms of glucose metabolism and transport, research in rodents suggests that isoleucine reduces blood glucose levels by enhancing the uptake of glucose by skeletal muscle cells, increasing the overall breakdown of glucose into energy, and reducing the amount of glucose produced by the liver (hepatic gluconeogenesis).[1][2]
How does isoleucine work?
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•Last Updated: May 16, 2025
Isoleucine is an amino acid that is essential for protein synthesis, muscle growth, and recovery. It may also lower blood glucose levels by improving glucose uptake in skeletal muscle, increasing glucose breakdown for energy, and decreasing glucose production in the liver.